1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. mAChR
    Phosphodiesterase (PDE)
  3. Irsogladine maleate

Irsogladine maleate (Synonyms: Dicloguamine maleate; MN1695)

Cat. No.: HY-B0327A
Handling Instructions

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.

For research use only. We do not sell to patients.

Irsogladine maleate Chemical Structure

Irsogladine maleate Chemical Structure

CAS No. : 84504-69-8

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Description

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4; mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

Clinical Trial
Molecular Weight

372.16

Formula

C₁₃H₁₁Cl₂N₅O₄

CAS No.

84504-69-8

SMILES

O=C(O)/C=C\C(O)=O.NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1

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Keywords:

IrsogladineDicloguamine MN1695MN1695MN 1695MN-1695mAChRPhosphodiesterase (PDE)Muscarinic acetylcholine receptorInhibitorinhibitorinhibit

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Irsogladine maleate
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