Irsogladine maleate
Based on 3 publication(s) in Google Scholar
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 84504-69-8
- Formula: C13H11Cl2N5O4
- Molecular Weight:372.16
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Irsogladine maleate
More
Biological Activity
Description
IC50 & Target
|
PDE4 |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 84504-69-8
-
Appearance Solid
-
Molecular Weight 372.16
-
Formula C13H11Cl2N5O4
-
Color White to off-white
-
SMILES
O=C(O)/C=C\C(O)=O.NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1
-
Synonyms
Dicloguamine maleate; MN1695
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Solvent & Solubility
In Vitro:
DMSO : 30 mg/mL (80.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Ren, C.J., et al., Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res, 1998. 77(2): p. 126-31. [Content Brief]
[2]. Kawasaki, Y., et al., Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas, 2002. 25(4): p. 373-7. [Content Brief]
[3]. Kyoi, T., et al., Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci, 2004. 75(15): p. 1833-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6870 mL | 13.4351 mL | 26.8702 mL | 67.1754 mL |
| 5 mM | 0.5374 mL | 2.6870 mL | 5.3740 mL | 13.4351 mL | |
| 10 mM | 0.2687 mL | 1.3435 mL | 2.6870 mL | 6.7175 mL | |
| 15 mM | 0.1791 mL | 0.8957 mL | 1.7913 mL | 4.4784 mL | |
| 20 mM | 0.1344 mL | 0.6718 mL | 1.3435 mL | 3.3588 mL | |
| 25 mM | 0.1075 mL | 0.5374 mL | 1.0748 mL | 2.6870 mL | |
| 30 mM | 0.0896 mL | 0.4478 mL | 0.8957 mL | 2.2392 mL | |
| 40 mM | 0.0672 mL | 0.3359 mL | 0.6718 mL | 1.6794 mL | |
| 50 mM | 0.0537 mL | 0.2687 mL | 0.5374 mL | 1.3435 mL | |
| 60 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1196 mL | |
| 80 mM | 0.0336 mL | 0.1679 mL | 0.3359 mL | 0.8397 mL |
Irsogladine maleate Related Classifications
HY-B0327A Related Classifications
Powered by Bioz