1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. mAChR
    Phosphodiesterase (PDE)
  3. Irsogladine

Irsogladine (Synonyms: Dicloguamine)

Cat. No.: HY-B0327 Purity: 95.13%
Handling Instructions

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.

For research use only. We do not sell to patients.

Irsogladine Chemical Structure

Irsogladine Chemical Structure

CAS No. : 57381-26-7

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10 mM * 1 mL in DMSO USD 55 In-stock
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500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4; mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

Clinical Trial
Molecular Weight

256.09

Formula

C₉H₇Cl₂N₅

CAS No.

57381-26-7

SMILES

NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 2.6 mg/mL (10.15 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9049 mL 19.5244 mL 39.0488 mL
5 mM 0.7810 mL 3.9049 mL 7.8098 mL
10 mM 0.3905 mL 1.9524 mL 3.9049 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

IrsogladineDicloguaminemAChRPhosphodiesterase (PDE)Muscarinic acetylcholine receptorInhibitorinhibitorinhibit

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