1. GPCR/G Protein
  2. Guanylate Cyclase

BAY 41-2272 

Cat. No.: HY-12376 Purity: 99.93%
Data Sheet SDS Handling Instructions

BAY 41-2272 is a soluble guanylate cyclases (sGC) activator.

For research use only. We do not sell to patients.
BAY 41-2272 Chemical Structure

BAY 41-2272 Chemical Structure

CAS No. : 256376-24-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
5 mg USD 96 In-stock
10 mg USD 168 In-stock
25 mg USD 348 In-stock
50 mg USD 552 In-stock
100 mg USD 984 In-stock
200 mg   Get quote  
500 mg   Get quote  

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BAY 41-2272 is a soluble guanylate cyclases (sGC) activator. Target: guanylate cyclase BAY 41-2272 is a recently introduced novel orally available agent that directly stimulates soluble guanylate cyclase (sGC) and sensitizes it to its physiological stimulator, nitric oxide. BAY 41-2272 is a promising new therapeutic agent that goes beyond current therapeutic agents. BAY 41-2272 acts as an arterial vasodilator, resulting in a reduction of MAP and pulmonary artery pressure and a decrease in SVR and renal vascular resistance. BAY 41-2272 reduces pulmonary capillary wedge pressure in the absence of a decrease in right atrial pressure. [2]

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.7748 mL 13.8739 mL 27.7477 mL
5 mM 0.5550 mL 2.7748 mL 5.5495 mL
10 mM 0.2775 mL 1.3874 mL 2.7748 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 17.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.93%

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