L-869298
L-869298 is a potent and selective PDE4 inhibitor with an IC50 of 0.5 nM for PDE4A. L-869298 shows less active against hERG potassium channel.
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- CAS No.: 362718-73-8
- Formule: C23H18F8N2O4S
- Masse moléculaire:570.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PDE4A 0.5 nM (IC50) |
Chemical Information
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CAS No. 362718-73-8
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Masse moléculaire 570.45
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Formule C23H18F8N2O4S
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SMILES
OC(C(F)(F)F)(C1=NC=C(S1)[C@@H](CC2=C[N+]([O-])=CC=C2)C3=CC=C(C(OC4CC4)=C3)OC(F)F)C(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Richard W Friesen, et al. Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity. J Med Chem. 2003 Jun 5;46(12):2413-26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-869298 Related Classifications
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