2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. MK-0952

MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study.

For research use only. We do not sell to patients.

MK-0952 Chemical Structure

MK-0952 Chemical Structure

CAS No. : 934995-87-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 649 In-stock
Solution
10 mM * 1 mL in DMSO USD 649 In-stock
Solid
1 mg USD 220 In-stock
5 mg USD 610 In-stock
10 mg USD 950 In-stock
25 mg USD 1900 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

MK-0952 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • Purity & Documentation

  • References

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Description

MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].

IC50 & Target[1]

PDE4

0.53 nM (IC50)

In Vivo

MK-0952 (10 mg/kg) induces malaise in the rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

483.49

Formula

C28H22FN3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@H](C2=CC=C(C3=CC=CC(N4C=C(C(NC5CC5)=O)C(C6=C4N=CC=C6)=O)=C3)C=C2F)C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0683 mL 10.3415 mL 20.6830 mL
5 mM 0.4137 mL 2.0683 mL 4.1366 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0683 mL 10.3415 mL 20.6830 mL 51.7074 mL
5 mM 0.4137 mL 2.0683 mL 4.1366 mL 10.3415 mL
10 mM 0.2068 mL 1.0341 mL 2.0683 mL 5.1707 mL
15 mM 0.1379 mL 0.6894 mL 1.3789 mL 3.4472 mL
20 mM 0.1034 mL 0.5171 mL 1.0341 mL 2.5854 mL
25 mM 0.0827 mL 0.4137 mL 0.8273 mL 2.0683 mL
30 mM 0.0689 mL 0.3447 mL 0.6894 mL 1.7236 mL
40 mM 0.0517 mL 0.2585 mL 0.5171 mL 1.2927 mL
50 mM 0.0414 mL 0.2068 mL 0.4137 mL 1.0341 mL
60 mM 0.0345 mL 0.1724 mL 0.3447 mL 0.8618 mL
80 mM 0.0259 mL 0.1293 mL 0.2585 mL 0.6463 mL
100 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5171 mL
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MK-0952 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0952934995-87-6MK0952MK 0952Phosphodiesterase (PDE)Alzheimer’sdiseaseInhibitorinhibitorinhibit

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