1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. MK-0952

MK-0952 

Cat. No.: HY-11070
Handling Instructions

MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study.

For research use only. We do not sell to patients.

MK-0952 Chemical Structure

MK-0952 Chemical Structure

CAS No. : 934995-87-6

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Description

MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].

IC50 & Target[1]

PDE4

0.53 nM (IC50)

In Vivo

MK-0952 (10 mg/kg) induces malaise in the rat[1].

Molecular Weight

483.49

Formula

C₂₈H₂₂FN₃O₄

CAS No.

934995-87-6

SMILES

O=C([[email protected]]1[[email protected]](C2=CC=C(C3=CC=CC(N4C=C(C(NC5CC5)=O)C(C6=C4N=CC=C6)=O)=C3)C=C2F)C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MK-0952MK0952MK 0952Phosphodiesterase (PDE)Alzheimer’sdiseaseInhibitorinhibitorinhibit

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MK-0952
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