934995-87-6
934995-87-6
Chemical Structure
MK-0952
- CAS No.: 934995-87-6
- Formula:C28H22FN3O4
- Molecular Weight:483.49
IUPAC Name: (1R,2R)-2-(3'-(3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid
InChIKey: PSYPBAHXIIVDCJ-FCHUYYIVSA-N
SMILES: O=C([C@H]1[C@H](C2=CC=C(C3=CC=CC(N4C=C(C(NC5CC5)=O)C(C6=C4N=CC=C6)=O)=C3)C=C2F)C1)O
Biological Activity: MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].
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MK-0952 | 99.71% | MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study. | ||||||||||||||||||||
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References
- [1]. Michel Gallant, et al. Discovery of MK-0952, a Selective PDE4 Inhibitor for the Treatment of Long-Term Memory Loss and Mild Cognitive Impairment. Epub 2010 Sep 21. [Content Brief]
- [2]. Tingting Pan, et al. Dual Functional Cholinesterase and PDE4D Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis and Evaluation of tacrine-pyrazolo[3,4-b]pyridine Hybrids. Behav Brain Res. 2016 Apr 15;303:26-33. [Content Brief]
Keywords
