2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE4-IN-16

PDE4-IN-16 (compound 27) is a PDE4 inhibitor with an IC50 value of 3.61 μM. PDE4-IN-16 can be used for the research of inflammatory diseases and central nervous system (CNS) disorders involving elevated levels of cytokines.

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PDE4-IN-16

PDE4-IN-16 Chemical Structure

CAS No. : 223500-15-0

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Based on 1 publication(s) in Google Scholar

PDE4-IN-16 Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

PDE4-IN-16 (compound 27) is a PDE4 inhibitor with an IC50 value of 3.61 μM. PDE4-IN-16 can be used for the research of inflammatory diseases and central nervous system (CNS) disorders involving elevated levels of cytokines[1].

IC50 & Target

IC50: 3.61 μM (PDE4)[1].
Molecular Weight

299.25

Formula

C13H12F3N3O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=C(C(F)(F)F)N(C2=CC=C(N)C=C2)N=C1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 45 mg/mL (150.38 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3417 mL 16.7084 mL 33.4169 mL
5 mM 0.6683 mL 3.3417 mL 6.6834 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3417 mL 16.7084 mL 33.4169 mL 83.5422 mL
5 mM 0.6683 mL 3.3417 mL 6.6834 mL 16.7084 mL
10 mM 0.3342 mL 1.6708 mL 3.3417 mL 8.3542 mL
15 mM 0.2228 mL 1.1139 mL 2.2278 mL 5.5695 mL
20 mM 0.1671 mL 0.8354 mL 1.6708 mL 4.1771 mL
25 mM 0.1337 mL 0.6683 mL 1.3367 mL 3.3417 mL
30 mM 0.1114 mL 0.5569 mL 1.1139 mL 2.7847 mL
40 mM 0.0835 mL 0.4177 mL 0.8354 mL 2.0886 mL
50 mM 0.0668 mL 0.3342 mL 0.6683 mL 1.6708 mL
60 mM 0.0557 mL 0.2785 mL 0.5569 mL 1.3924 mL
80 mM 0.0418 mL 0.2089 mL 0.4177 mL 1.0443 mL
100 mM 0.0334 mL 0.1671 mL 0.3342 mL 0.8354 mL
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PDE4-IN-16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4-IN-16223500-15-0Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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