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ionophore

" in MedChemExpress (MCE) Product Catalog:

85

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1

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2

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4

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32

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5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13434
    Ionomycin
    115+ Cited Publications

    SQ23377

    		 Calcium Channel PKC Bacterial Apoptosis Antibiotic Infection Cancer
    Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .
    Ionomycin
  • HY-12040
    Elesclomol
    110+ Cited Publications

    STA-4783

    		 Reactive Oxygen Species (ROS) Apoptosis Cuproptosis Cancer
    Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .
    Elesclomol
  • HY-127019
    Nigericin
    Maximum Cited Publications
    221 Publications Verification

    		 Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin Infection Cancer
    Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .
    Nigericin
  • HY-N6687
    Calcimycin
    20+ Cited Publications

    A-23187; Antibiotic A-23187

    		 Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .
    Calcimycin
  • HY-100381
    Nigericin sodium salt
    Maximum Cited Publications
    221 Publications Verification

    		 Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin Infection Cancer
    Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .
    Nigericin sodium salt
  • HY-13434A
    Ionomycin calcium
    115+ Cited Publications

    SQ23377 calcium

    		 Calcium Channel PKC Bacterial Apoptosis Antibiotic Infection Cancer
    Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .
    Ionomycin calcium
  • HY-N0150
    Monensin sodium
    35+ Cited Publications

    Monensin A sodium

    		 Exosomes Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt Infection Cancer
    Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na +/H + exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .
    Monensin sodium
  • HY-N6693
    Valinomycin
    5+ Cited Publications

    NSC 122023

    		 Apoptosis Antibiotic Autophagy Fungal Infection Others Cancer
    Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .
    Valinomycin
  • HY-15597
    Salinomycin
    45+ Cited Publications

    Procoxacin

    		 Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite Cancer
    Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells .
    Salinomycin
  • HY-17439
    Salinomycin sodium salt
    45+ Cited Publications

    Salinomycin sodium; Sodium salinomycin

    		 Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite Cancer
    Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells .
    Salinomycin sodium salt
  • HY-108611
    AACOCF3
    4 Publications Verification

    Arachidonyl trifluoromethyl ketone

    		 Phospholipase Cardiovascular Disease
    AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
    AACOCF3
  • HY-B0572
    Zinc Pyrithione
    10+ Cited Publications

    		 Environmental Pollutants Bacterial Cuproptosis Proton Pump Fungal Infection Metabolic Disease
    Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .
    Zinc Pyrithione
  • HY-B1327
    Chlortetracycline hydrochloride
    5+ Cited Publications

    7-Chlorotetracycline hydrochloride

    		 Bacterial Antibiotic Parasite Infection Inflammation/Immunology
    Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes .
    Chlortetracycline hydrochloride
  • HY-B1071
    Lasalocid
    4 Publications Verification

    Lasalocid-A; ionophore X-537A; Antibiotic X-537A

    		 Antibiotic Bacterial Autophagy Parasite Apoptosis Infection Cancer
    Lasalocid (Lasalocid-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid exhibits antitumor activity. Lasalocid is orally active .
    Lasalocid
  • HY-B1071A
    Lasalocid sodium
    4 Publications Verification

    Lasalocid-A sodium; ionophore X-537A sodium; Antibiotic X-537A sodium

    		 Antibiotic Bacterial Autophagy Parasite Apoptosis Infection Cancer
    Lasalocid sodium (Lasalocid sodium-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid sodium exhibits antitumor activity. Lasalocid sodium is orally active .
    Lasalocid sodium
  • HY-N6790
    Nonactin

    Ammonium ionophore I

    		 Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP Infection Cancer
    Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K +, and NH4 +, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .
    Nonactin
  • HY-105321
    PBT 1033

    PBT 2

    		 Bacterial Neurological Disease
    PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .
    PBT 1033
  • HY-101109
    Sodium ionophore III
    1 Publications Verification

    ETH2120

    		 Sodium Channel Cardiovascular Disease
    Sodium ionophore III (ETH2120) is a Na + ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc.
    Sodium ionophore III
  • HY-N4302
    Monensin
    35+ Cited Publications

    Monensin A

    		 Exosomes Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt Infection Cancer
    Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na +/H + exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .
    Monensin
  • HY-136460
    Calcium ionophore I

    ETH 1001

    		 Calcium Channel Others
    Calcium ionophore I (ETH 1001) is a selective Ca 2+ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .
    Calcium ionophore I
  • HY-B1327A
    Chlortetracycline

    7-Chlorotetracycline

    		 Bacterial Antibiotic Parasite Infection Inflammation/Immunology
    Chlortetracycline (7-Chlorotetracycline) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes .
    Chlortetracycline
  • HY-W020249
    Sodium ionophore X

    		Biochemical Assay Reagents Others
    Sodium ionophore X is a neutral ionophore that binds highly selectively to sodium ions (Na +) to form stable complexes. Sodium ionophore X can be used to construct ion-selective chemical sensors (including optical sensors and electrochemical sensors) .
    Sodium ionophore X
  • HY-12361
    PF 1022A
    1 Publications Verification

    		 Parasite Infection
    PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research .
    PF 1022A
  • HY-121410
    Narasin
    2 Publications Verification

    		 Bacterial Apoptosis Parasite NF-κB Antibiotic Infection Cancer
    Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways .
    Narasin
  • HY-P2324
    Gramicidin A
    1 Publications Verification

    		 Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic Infection Cancer
    Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
    Gramicidin A
  • HY-P3003
    Cereulide

    		Potassium Channel Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism Infection Neurological Disease Metabolic Disease Inflammation/Immunology
    Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K +, and transports K + from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning .
    Cereulide
  • HY-112825
    TSI-01

    		Platelet-activating Factor Receptor (PAFR) Inflammation/Immunology
    TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s=0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). 60 μM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
    TSI-01
  • HY-162386
    UM4118

    		Cuproptosis Mitochondrial Metabolism Cancer
    UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .
    UM4118
  • HY-125703
    Ferutinin

    		Estrogen Receptor/ERR Apoptosis Infection Inflammation/Immunology Endocrinology Cancer
    Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca 2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .
    Ferutinin
  • HY-N6694
    4-Bromo A23187

    		Calcium Channel Bacterial Apoptosis Antibiotic Infection Cancer
    4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells .
    4-Bromo A23187
  • HY-155254
    Sodium ionophore VI

    		Biochemical Assay Reagents Others
    Sodium ionophore VI is a sodium ionophore that has been employed for developing cation optical sensors .
    Sodium ionophore VI
  • HY-139728
    N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide

    Calcium ionophore II

    		 Biochemical Assay Reagents Others
    N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode .
    N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide
  • HY-75200
    N-(Benzyloxycarbonyloxy)succinimide

    		Biochemical Assay Reagents Others
    N-(Benzyloxycarbonyloxy)succinimide is an efficient amino-protecting reagent in organic synthesis, playing an important role in the field of organic synthesis. N-(Benzyloxycarbonyloxy)succinimide is also a neutral ionophore, which significantly improves the performance of erbium ion (Er 3+) sensors and provides a practical tool for the rapid detection of erbium ions in the environment and water quality .
    N-(Benzyloxycarbonyloxy)succinimide
  • HY-B1327S
    Chlortetracycline-d6 hydrochloride

    7-Chlorotetracycline-d6 hydrochloride

    		 Bacterial Antibiotic Infection
    Chlortetracycline-d6 (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.
    Chlortetracycline-d6 hydrochloride
  • HY-10437
    Setileuton

    MK-0633

    		 Lipoxygenase Inflammation/Immunology
    Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively .
    Setileuton
  • HY-106200
    CJ-13,610

    		Lipoxygenase Inflammation/Immunology
    CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC50 of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid
    CJ-13,610
  • HY-167843
    Alborixin

    		Akt Autophagy PTEN Amyloid-β Antibiotic Bacterial Fungal Infection Neurological Disease
    Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease .
    Alborixin
  • HY-N0150R
    Monensin sodium (Standard)

    Monensin A sodium (Standard)

    		 Reference Standards Exosomes Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt Infection Cancer
    Monensin (sodium) (Standard) is the analytical standard of Monensin (sodium). This product is intended for research and analytical applications. Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .
    Monensin sodium (Standard)
  • HY-D1896
    Chloride Ionophore IV

    		Fluorescent Dye Others
    Chloride Ionophore IV is a thiourea type hydrogen bonding-based receptor. Chloride Ionophore IV is a chloride ionophore .
    Chloride Ionophore IV
  • HY-W653977
    Chlortetracycline-13C,d3 hydrochloride

    7-Chlorotetracycline-13C,d3 hydrochloride

    		 Isotope-Labeled Compounds Antibiotic Bacterial Parasite Infection
    Chlortetracycline-13C,d3 hydrochloride (7-Chlorotetracycline-13C,d3 hydrochloride) is the 13C- and deuterium labeled Chlortetracycline hydrochloride (HY-B1327). Chlortetracycline hydrochloride is an orally active, selective antibiotic, that inhibits methanogenic bacteria through inhibition of bacterial protein synthesis. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, that inhibits binding of aminoacyl-tRNA to ribosomes .
    Chlortetracycline-13C,d3 hydrochloride
  • HY-P3003S
    Cereulide-13C6

    		Isotope-Labeled Compounds Apoptosis Potassium Channel Mitochondrial Metabolism Autophagy Reactive Oxygen Species (ROS) Infection Neurological Disease Metabolic Disease Inflammation/Immunology
    Cereulide- 13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K +, and transports K + from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.
    Cereulide-13C6
  • HY-W674112
    Magnesium ionophore I

    ETH 1117

    		 Endogenous Metabolite Others
    Magnesium ionophore I (ETH 1117) serves as the primary component for the development of calcium-magnesium selective electrodes.
    Magnesium ionophore I
  • HY-17439R
    Salinomycin sodium salt (Standard)

    Salinomycin sodium (Standard); Sodium salinomycin (Standard)

    		 Reference Standards Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite Cancer
    Salinomycin (sodium salt) (Standard) is the analytical standard of Salinomycin (sodium salt). This product is intended for research and analytical applications. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .
    Salinomycin sodium salt (Standard)
  • HY-178914
    Copper ionophore I

    		Cuproptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    Copper ionophore I is an efficient copper ion carrier. Copper ionophore I can regulate various intracellular copper levels to induce cuproptosis, such as 4T1 (IC50 = 0.45 μM) and MDA-MB-231(IC50 = 1.21 μM) cells. Copper ionophore I can induce an increase in ROS and cause mitochondrial dysfunction. Copper ionophore I can reduce the expression of FDX1, DLAT, and LIAS proteins. Copper ionophore I can activate immune related pathways and promote T cell infiltration. Copper ionophore I can be used for cancer research .
    Copper ionophore I
  • HY-112225
    Narasin sodium

    		Antibiotic Bacterial Parasite NF-κB Apoptosis Infection Cancer
    Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin sodium has antimicrobial and anticancer activity .
    Narasin sodium
  • HY-W783917
    Lead Ionophore IV

    		Biochemical Assay Reagents Endogenous Metabolite
    Lead Ionophore IV is an ionophore that has the activity of promoting metal ion transport. Lead Ionophore IV is often used in biological research to study the biological effects of lead ions and their effects on cell function. Lead Ionophore IV can also be used to develop drug delivery systems to improve the bioavailability of compounds.
    Lead Ionophore IV
  • HY-W783680
    Potassium ionophore III

    		Potassium Channel Others
    Potassium ionophore III (BME-44) is a specific potassium ion carrier with high selectivity for sodium and ammonium ions and high lipophilicity .
    Potassium ionophore III
  • HY-111525
    Monactin

    		Oxidative Phosphorylation Bacterial Antibiotic Infection
    Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .
    Monactin
  • HY-105321A
    PBT 1033 hydrochloride

    PBT 2 hydrochloride

    		 Bacterial Neurological Disease
    PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .
    PBT 1033 hydrochloride
  • HY-N6687B
    Calcimycin hemimagnesium

    A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium

    		 Oxidative Phosphorylation Antibiotic Bacterial Fungal Apoptosis Autophagy Infection Cancer
    Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis and autophagy .
    Calcimycin hemimagnesium

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