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  3. Ferutinin

Ferutinin 

Cat. No.: HY-125703
Handling Instructions

Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.

For research use only. We do not sell to patients.

Ferutinin Chemical Structure

Ferutinin Chemical Structure

CAS No. : 41743-44-6

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Description

Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities[1][2].

IC50 & Target[1]

ERα

33.1 nM (IC50)

ERβ

180.5 nM (IC50)

In Vitro

Ferutinin manifested antiproliferative activity, inducing apoptosis in several cell types: MCF-7 estrogen-dependent cancer cells, leukemia T-cell line (Jurkat), human and mouse colon carcinoma cells (Caco-2, CT26, HT29), as well as bladder (TCC) cancer cells. Ferutinin potentiates bone mineralization, and is proposed to be used as an antiosteoporosis phytoestrogen[2].
Ferutinin considerably increases the permeability of artificial and cellular membranes to Ca2+-ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. Ferutinin alone (10-60 µM) also dose-dependently dissipated membrane potential. In the presence of Ca2+-ions, Ferutinin (10-60 µM) induces considerable depolarization of the inner mitochondrial membrane[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.47

Formula

C22H30O4

CAS No.
SMILES

O=C(O[[email protected]@H]1[[email protected]@]2([H])[[email protected]@](C(C)C)(O)CC[[email protected]]2(C)CC=C(C)C1)C3=CC=C(O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Ferutinin
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