Lasalocid sodium (Synonyms: Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium)

Name: Lasalocid sodium
Brand: MedChemExpress
SKU: HY-B1071A
Rating: 5.0 (3 reviews)

Cat. No.: HY-B1071A Purity: 98.28%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Lasalocid sodium (Lasalocid-A sodium) is an antibacterial agent.

For research use only. We do not sell to patients.

Lasalocid sodium Chemical Structure

CAS No. : 25999-20-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Lasalocid sodium:

Lasalocid In-stock
Lasalocid (sodium) (Standard) Get quote

3 Publications Citing Use of MCE Lasalocid sodium

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Lasalocid sodium (Lasalocid-A sodium) is an antibacterial agent.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.8 μM Compound: 1, Lasalocid	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 23932361]
BALB/3T3	IC₅₀	7.35 μM Compound: 1, Lasalocid	Cytotoxicity against mouse BALB/3T3 cells after 72 hrs by SRB assay Cytotoxicity against mouse BALB/3T3 cells after 72 hrs by SRB assay	[PMID: 23932361]
HeLa	EC₅₀	2 μM Compound: Lasalocid	Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in [14C]-leucine incorporation incubated with cells for 3 hrs prior to Stx1 addition and further incubated for overnight and subsequ Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in [14C]-leucine incorporation incubated with cells for 3 hrs prior to Stx1 addition and further incubated for overnight and subsequ	[PMID: 32648758]
HT-29	IC₅₀	1.95 μM Compound: 1, Lasalocid	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 23932361]
MCF7	IC₅₀	3.12 μM Compound: 1, Lasalocid	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23932361]
P388	IC₅₀	4.54 μM Compound: 1, Lasalocid	Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay	[PMID: 23932361]

In Vitro

Lasalocid (2.5 μg/mL) sodium inhibits the growth of white spot bacteria, yellow spot bacteria, and fibrinolytic vibrio^[1].
Lasalocid sodium works in the rumen by selectively promoting the growth of succinate-producing Bacteroides and S. ruminantium, which can lead to an increased formation of propionate in the rumen^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

612.77

Formula

C₃₄H₅₃NaO₈

CAS No.

25999-20-6

Appearance

Solid

Color

White to yellow

SMILES

O=C(O[Na])C1=C(CC[C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@H]2O[C@@]([C@H]3CC[C@](O)(CC)[C@H](C)O3)(CC)C[C@@H]2C)CC)=O)C=CC(C)=C1O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Streptomyces lasaliensis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (163.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6319 mL	8.1597 mL	16.3193 mL
5 mM	0.3264 mL	1.6319 mL	3.2639 mL
10 mM	0.1632 mL	0.8160 mL	1.6319 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.28%

Select Batch:

Data Sheet (278 KB) SDS (605 KB)

COA (258 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Chen M, et al. Effect of monensin and lasalocid-sodium on the growth of methanogenic and rumen saccharolytic bacteria. Appl Environ Microbiol. 1979 Jul;38(1):72-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6319 mL	8.1597 mL	16.3193 mL	40.7983 mL
	5 mM	0.3264 mL	1.6319 mL	3.2639 mL	8.1597 mL
	10 mM	0.1632 mL	0.8160 mL	1.6319 mL	4.0798 mL
	15 mM	0.1088 mL	0.5440 mL	1.0880 mL	2.7199 mL
	20 mM	0.0816 mL	0.4080 mL	0.8160 mL	2.0399 mL
	25 mM	0.0653 mL	0.3264 mL	0.6528 mL	1.6319 mL
	30 mM	0.0544 mL	0.2720 mL	0.5440 mL	1.3599 mL
	40 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0200 mL
	50 mM	0.0326 mL	0.1632 mL	0.3264 mL	0.8160 mL
	60 mM	0.0272 mL	0.1360 mL	0.2720 mL	0.6800 mL
	80 mM	0.0204 mL	0.1020 mL	0.2040 mL	0.5100 mL
	100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.4080 mL

Lasalocid sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lasalocid25999-20-6Lasalocid-AIonophore X-537AAntibiotic X-537ABacterialAutophagyAntibioticParasiteAntibacterialInhibitorinhibitorinhibit

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Lasalocid sodium (Synonyms: Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium)

Customer Review

Other Forms of Lasalocid sodium:

Lasalocid sodium Related Antibodies

3 Publications Citing Use of MCE Lasalocid sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Parasite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Lasalocid sodium Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Lasalocid sodium Related Classifications

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