Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis
- Antimicrob Agents Chemother. 1997 Jan;41(1):191-2. doi: 10.1128/AAC.41.1.191.
Affiliations
- 1. Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis Tennessee 38105, USA.
PMID: 8980779
DOI: 10.1128/AAC.41.1.191
Abstract
The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii Infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with Other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.
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