Dinactin
Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 μM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain.
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- CAS. Nr.: 20261-85-2
- Formel: C42H68O12
- Molecular Weight:764.98
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml for M.tuberculosis(ATCC 25177), S. epidermidis(ATCC 12228), M. luteus(ATCC10240), S. aureus(ATCC 35923), E. faecalis(ATCC 51299), B. subtilis(ATCC 11774), E. coli(ATCC 10536), P. aeruginosa(ATCC 10145), K. pneumonia(ATCC BAA-2146) strain, respectively[1].
Dinactin (0-100 μM) shows antitumor activity with IC50 values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 μM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively[1].
Dinactin (0.5, 1, 2 μM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells[1].
inactin (0.5, 1, 2 μM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 20261-85-2
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Molecular Weight 764.98
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Formel C42H68O12
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SMILES
CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3CC)=O)C)CC5)C)=O)C)([H])CC4
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Initial Source
Streptomyces aureus
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Dinactin Related Classifications
HY-121333 Related Classifications
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