Phlorofucofuroeckol A
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease.
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- No. CAS: 128129-56-6
- Fòrmula: C30H18O14
- Peso molecular:602.46
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Almacenamiento:
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
174.6 μM
Compound: 9
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Inhibition of SARS coronavirus 3C-like protease cis-cleavage activity transfected in african green monkey Vero cells using SAVLQSGFRK as substrate after 5 hrs by luciferase reporter gene assay
Inhibition of SARS coronavirus 3C-like protease cis-cleavage activity transfected in african green monkey Vero cells using SAVLQSGFRK as substrate after 5 hrs by luciferase reporter gene assay
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[PMID: 23647823] |
Phlorofucofuroeckol A (10-100 μM; 48 h) shows no significant cytotoxicity toward KU812 and RBL-2H3 cells[1].
Phlorofucofuroeckol A (10-100 μM; 30 min) dose-dependently inhibits IgE/anti-IgE-induced histamine release in KU812 cells, with an IC50 of 65.81 μM, and reduces relative histamine release to 34.54% at 100 μM after pre-incubation[1].
Phlorofucofuroeckol A (10-100 μM; 30 min) dose-dependently inhibits A23187-induced histamine release in RBL-2H3 cells, with an IC50 of 64.06 μM, and reduces relative histamine release to 34.18% at 100 μM after pre-incubation[1].
Phlorofucofuroeckol A (10-100 μM) dose-dependently inhibits IgE/DNP-BSA-induced β-hexosaminidase release in RBL-2H3 cells, with an IC50 of 38.87 μM, and reduces relative β-hexosaminidase release to 20.80% at 100 μM[1].
Phlorofucofuroeckol A (12.5-50 μM) dose-dependently inhibits IgE-FcεRI binding on KU812F cells, reducing the percentage of positive cells to 79.51%, 57.58%, and 34.23% at 12.5, 25, and 50 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human basophilic leukemia KU812 cells, rat basophilic leukemia RBL-2H3 cells
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Concentration:10-100 μM
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Incubation Time:48 h
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Result:Exerted no significant cytotoxic effects on KU812 or RBL-2H3 cells.
Maintained cell viability above 95% across all tested concentrations.
Chemical Information
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No. CAS 128129-56-6
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Peso molecular 602.46
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Fòrmula C30H18O14
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SMILES
OC1=CC(OC2=C(C=C(C(OC3=C4C5=C(O)C=C(O)C(OC6=CC(O)=CC(O)=C6)=C5OC4=C7)=C2OC3=C7O)O)O)=CC(O)=C1
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Structure Classification
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Initial Source
Ecklonia stolonifera
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phlorofucofuroeckol A Related Classifications
HY-N11725 Related Classifications
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