2. Immunology/Inflammation
  3. Fc Receptor (FcR)
  4. Phlorofucofuroeckol A

Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease.

For research use only. We do not sell to patients.

Phlorofucofuroeckol A

Phlorofucofuroeckol A Chemical Structure

CAS No. : 128129-56-6

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Phlorofucofuroeckol A Related Antibodies

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Description

Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease[1].

In Vitro

Phlorofucofuroeckol A (10-100 μM; 48 h) shows no significant cytotoxicity toward KU812 and RBL-2H3 cells[1].
Phlorofucofuroeckol A (10-100 μM; 30 min) dose-dependently inhibits IgE/anti-IgE-induced histamine release in KU812 cells, with an IC50 of 65.81 μM, and reduces relative histamine release to 34.54% at 100 μM after pre-incubation[1].
Phlorofucofuroeckol A (10-100 μM; 30 min) dose-dependently inhibits A23187-induced histamine release in RBL-2H3 cells, with an IC50 of 64.06 μM, and reduces relative histamine release to 34.18% at 100 μM after pre-incubation[1].
Phlorofucofuroeckol A (10-100 μM) dose-dependently inhibits IgE/DNP-BSA-induced β-hexosaminidase release in RBL-2H3 cells, with an IC50 of 38.87 μM, and reduces relative β-hexosaminidase release to 20.80% at 100 μM[1].
Phlorofucofuroeckol A (12.5-50 μM) dose-dependently inhibits IgE-FcεRI binding on KU812F cells, reducing the percentage of positive cells to 79.51%, 57.58%, and 34.23% at 12.5, 25, and 50 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phlorofucofuroeckol A Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human basophilic leukemia KU812 cells, rat basophilic leukemia RBL-2H3 cells
Concentration: 10-100 μM
Incubation Time: 48 h
Result: Exerted no significant cytotoxic effects on KU812 or RBL-2H3 cells.
Maintained cell viability above 95% across all tested concentrations.
Molecular Weight

602.46

Formula

C30H18O14
CAS No.
SMILES

OC1=CC(OC2=C(C=C(C(OC3=C4C5=C(O)C=C(O)C(OC6=CC(O)=CC(O)=C6)=C5OC4=C7)=C2OC3=C7O)O)O)=CC(O)=C1
Structure Classification
Initial Source

Ecklonia stolonifera
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phlorofucofuroeckol A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phlorofucofuroeckol A128129-56-6Fc Receptor (FcR)Fc ReceptorKU812F cellsFcεRIhistamineallergy diseaseIgEcalcium ionophore A23187β-hexosaminidaseKU812 cellsRBL-2H3 cellsbasophilic leukemia cellsInhibitorinhibitorinhibit

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