Search Result

Results for "

root+bark

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (1) Apoptosis (4) Autophagy (1) Biochemical Assay Reagents (3) Caspase (1) COX (2) Drug Derivative (8) Fungal (6) Glycosidase (1) HIF/HIF Prolyl-Hydroxylase (2) HSV (1) Insecticide (3) Integrin (1) Interleukin Related (1) JNK (1) LDLR (1) Lipase (1) Lipoxygenase (1) MDM-2/p53 (1) NO Synthase (2) Opioid Receptor (1) Parasite (4) PARP (1) PD-1/PD-L1 (2) PGE synthase (1) Phosphatase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) STAT (2) TNF Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (2) Infection (12) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (2)

By Targets:

AP-1 (1)

Apoptosis (4)

Autophagy (1)

Biochemical Assay Reagents (3)

Caspase (1)

COX (2)

Drug Derivative (8)

Fungal (6)

Glycosidase (1)

HIF/HIF Prolyl-Hydroxylase (2)

HSV (1)

Insecticide (3)

Integrin (1)

Interleukin Related (1)

JNK (1)

LDLR (1)

Lipase (1)

Lipoxygenase (1)

MDM-2/p53 (1)

NO Synthase (2)

Opioid Receptor (1)

Parasite (4)

PARP (1)

PD-1/PD-L1 (2)

PGE synthase (1)

Phosphatase (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (4)

STAT (2)

TNF Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (2)

Infection (12)

Inflammation/Immunology (11)

Metabolic Disease (8)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1381

Periplocin Maximum Cited Publications 6 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-N2392

Kukoamine A 1 Publications Verification	Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE₂, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .

HY-N0242

Fraxinellone 4 Publications Verification	PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT	Inflammation/Immunology Cancer
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 .

HY-N0627

Kaempferol-7-O-β-D-glucopyranoside	LDLR	Others
Kaempferol-7-O-β-D-glucopyranoside is a flavonoid glycoside. Kaempferol-7-O-β-D-glucopyranoside exists in the root bark of Cudrania tricuspidata. Kaempferol-7-O-β-D-glucopyranoside inhibits Cu ²⁺-induced lipid peroxidation of low-density lipoprotein. Kaempferol-7-O-β-D-glucopyranoside possesses antioxidant activity and scavenges DPPH free radicals .

HY-N2300

Kuwanon A 1 Publications Verification	NO Synthase	Metabolic Disease Inflammation/Immunology
Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC₅₀ of 10.5 μM.

HY-N1931

Epifriedelanol	Caspase PARP Apoptosis MDM-2/p53	Cancer
Epifriedelanol is a triterpenoid found in the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells .

HY-N3395

Leachianone G	HSV	Infection
Leachianone G is an antiviral flavonoid from the root bark of Morus alba L. Leachianone G shows potent antiviral activity against herpes simplex type 1 virus (HSV-1) with an IC₅₀* value of 1.6 μg/mL .*

HY-N0672

Pseudolaric Acid C	Fungal	Infection
Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity .

HY-N8761

Kihadanin A	NO Synthase	Metabolic Disease
Kihadanin A (compound 3) is a limonoid NOS3 inhibitor that can be isolated from the methanol extract of Dictamnus dasycarpus root bark. Kihadanin A is useful in the study of hyperuricemia (HUA) [3].

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-N3944

Glaucin B 6β-Acetoxy-5-epilimonin	Others	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

HY-N10842

6-Formyllimetin	Others	Others
6-Formyllimetin is a natural product isolated from the root bark of T. asiatica LAM .

HY-N2299

Morusinol	Others	Cardiovascular Disease
Morusinol is a flavonoid isolated from Morus alba root bark. Morusinol has an antiplatelet activity and significantly inhibits arterial thrombosis in vivo .

HY-N10695

Celangulatin C	Parasite	Infection
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows LD₅₀ against Mythimna separata of 280.4 μg/mL .

HY-N10803

(+)-6-(3-Chloro-2-hydroxy-3-methylbutyl)-5,7-dimethoxycoumarin	Others	Others
(+)-6-(3-Chloro-2-hydroxy-3-methylbutyl)-5,7-dimethoxycoumarin is a nature product that could be isolated form the root bark of Toddalia asiatica (L.) LAM .

HY-N10854

Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-	Others	Others
Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo- is a lanosterane type compound. Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo- can be isolated from Tu-Jin-Pi (the root bark of Pseudolarix kaempferi) .

HY-N2159

Lancerin 1 Publications Verification	Others	Metabolic Disease
Lancerin, isolated from the root bark of Cudraniu cochinchinensis, possesses anti-lipid peroxidation .

HY-N11531

Kuwanon W	Others	Others
Kuwanon W is a natural product that can be isolated from the root bark of Morus lhou .

HY-N16130

Kuwanon S	Drug Derivative	Others
Kuwanon S is a flavonoid compound that can be isolated from the root bark of Morus alba L. Kuwanon S is commonly used in organic synthesis and biochemistry experiments .

HY-125123

Euchrestaflavanone A	Integrin	Cardiovascular Disease
Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis .

HY-N2906

Limonianin Atalantoflavone	Parasite	Cancer
Limonianin (Atalantoflavone) is a flavone, that can be isolated from Erythrina sigmoidea and the root bark of Citrus limonia. Limonianin presents inhibitory effect against P. gingivalis. Limonianin shows cytotoxic activity against multidrug-resistant (MDR) cancer cell lines .

HY-N10697

Angulatin G Celangulatin E	Parasite	Infection
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows LD₅₀ against Mythimna separata of 1656.4 μg/mL .

HY-N1381R

Periplocin (Standard)	Reference Standards Apoptosis	Inflammation/Immunology Cancer
Periplocin (Standard) is the analytical standard of Periplocin. This product is intended for research and analytical applications. Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-N4248

Perisesaccharide C	Others	Others
Perisesaccharide C is an oligosaccharide isolated from the root barks of Periploca sepium.

HY-N4249

Perisesaccharide B	Others	Others
Perisesaccharide B is an oligosaccharide isolated from the root barks of Periploca sepium.

HY-N5154

Sanggenon W	Others	Others
Sanggenon W is an isoprenyl flavonoid extracted from mulberry root bark .

HY-N4082

Neotriptophenolide	Others	Cancer
Neotriptophenolide is a sesquiterpene pyridine alkaloid isolated from the root barks of Tripterygium hypoglaucum .

HY-124915

Netzahualcoyondiol	Others	Others
Netzahualcoyondiol is a triterpene that can be isolated from m root bark of Cheiloclinium cognatum .

HY-N7871

Angulatin K	Others	Others
Angulatin K is a natural sesquiterpene polyol ester found in the root bark of Celastrus angulatus .

HY-N10745

Angulatin B	Others	Others
Angulatin B is a natural product that can be found in the root bark of Celastrus angulatus .

HY-N2979

Cabralealactone Dipterocarpon	Others	Others
Cabralealactone (Dipterocarpon) is a Alkaloids product that can be isolated from the root barks of Dictamnus dasycarpus. .

HY-N8283

Euchrestaflavanone B	Others	Others
Euchrestaflavanone B is a Flavonoids product that can be isolated from the root barks of Cudrania tricuspidata. .

HY-N8836

Sanggenon K	Others	Others
Sanggenon K is a Flavonoids product that can be isolated from the root barks of Morus alba L. .

HY-N3224

Myricanol triacetate	Others	Others
Myricanol triacetate is a Phenols product that can be isolated from the root barks of Myrica cerifera L. .

HY-N8026

Colutehydroquinone	Fungal	Infection
Colutehydroquinone is an isoflavonoid that can be found in the root bark of Colutea arborescens. Colutehydroquinone exhibits antifungal activity .

HY-N1197

Subelliptenone G 1,4,5-Trihydroxyxanthone	Others	Others
Subelliptenone G is a simple oxygenated xanthone that can be isolated from the root bark of Garcinia subelliptica .

HY-N10873

Pseudolarifuroic acid	Others	Others
Pseudolarifuroic acid (compound 4) is a nature product that could be isolated from the root bark of P. kaempferi .

HY-113757

Picrasidine M	Others	Others
Picrasidine M (compound II) is an alkaloid that can be isolated from the root bark of Picrasma quassinoids BENNET .

HY-N3137

O-Methylpallidine Fissistigine C; O-Methyl-(+)-flavinantine	Others	Others
O-Methylpallidine (Fissistigine C) is a Alkaloids product that can be isolated from the root barks of Melodinus yunnanensis .

HY-N10977

Piscerygenin	Others	Others
Piscerygenin (compound 4), an isoflavonoid, is a nature product that could be isolated from the root bark of Piscidia erythrina .

HY-N8783

Kuwanon B	Others	Others
Kuwanon B is a flavone derivative that can be found in the root bark of the cultivated mulberry tree (a variety of Morus alba L.) .

HY-N10318

Erigeside II Dictamnoside A	Fungal	Infection Others
Erigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells .

HY-119637

Frangufoline	Others	Others
Frangufoline is a 4(14)-type cyclopeptide alkaloid, that can be isolated from the root bark extract of Ziziphus cambodiana Pierre .

HY-N3448

Isowigtheone	Others	Cancer
Isowigtheone is a cytotoxic isoflavone compound isolated from the root barks of Brosimum utile. Isowigtheone has the potential for the research of cancer diseases .

HY-N13105

Camelliagenin A 16-tiglate	Others	Others
Camelliagenin A 16-tiglate (compound 6) is a camellia saponin isolated from the acid hydrolysis product of Harpullia cupanioides Roxb root bark saponin .

HY-N5053

Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside]	Others	Others
Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] is a cardenolide isolated from the root barks of Periploca sepium .

HY-N2159R

Lancerin (Standard)	Reference Standards Others	Metabolic Disease
Lancerin (Standard) is the analytical standard of Lancerin. This product is intended for research and analytical applications. Lancerin, isolated from the root bark of Cudraniu cochinchinensis, possesses anti-lipid peroxidation .

HY-N3563

Celaphanol A	Others	Neurological Disease
Celaphanol A is a diterpene that can be isolated from the root bark of Celastrus orbiculatus. Celaphanol A shows neuroprotective effect against a hydrogen peroxide-induced cytotoxicity in PC12 cells .

HY-N0672R

Pseudolaric Acid C (Standard)	Reference Standards Fungal	Infection
Pseudolaric Acid C (Standard) is the analytical standard of Pseudolaric Acid C. This product is intended for research and analytical applications. Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity .

HY-N10683

1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran	Others	Others
1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran is a sesquiterpenoid isolated from the root bark of Tripterygium hypoglaucum containing a benzoyl and a cinnamoyl group .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

root+bark

Inhibitors & Agonists

NaturalProducts

Natural
Products