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Cat. No.: HY-N17355

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Des-N-methylnoracronycine

Des-N-methylnoracronycine is an acridone alkaloid found in the root bark of Glycosmis pentaphylla (Retz.) Correa. Des-N-methylnoracronycine has antitumor and platelet aggregation inhibitory activities.

For research use only. We do not sell to patients.

CAS No.: 13396-93-5
Formula: C₁₈H₁₅NO₃
Molecular Weight:293.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Des-N-methylnoracronycine Chemical Structure

CAS No.: 13396-93-5

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.37 μM Compound: 13	Antiproliferative activity against human A549 cells after 3 days by alamar blue assay Antiproliferative activity against human A549 cells after 3 days by alamar blue assay	[PMID: 10217715]

In Vitro

Des-N-methylnoracronycine produces a green-colored reaction with ferric chloride^[1].
Des-N-methylnoracronycine (24 h) has IC₅₀ values of 6.37, 5.05, 3.10, and 2.07 μM for A-549, B-16, 4A5, CCRF-HSB-2, and TGBC11TKB, respectively^[2].
Des-N-methylnoracronycine (0-10 μM; 4 days) induces differentiation of HL-60 cells^[3].
Des-N-methylnoracronycine (100 μg/mL) inhibits platelet aggregation induced by Arachidonic Acid (HY-109590) and Collagen^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 13396-93-5
Molecular Weight 293.32
Formula C₁₈H₁₅NO₃
SMILES

O=C1C2=C(NC3=C4C=CC(C)(C)OC4=CC(O)=C13)C=CC=C2
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Govindachari T R, et al. Alkaloids of Glycosmis pentaphylla (Retz.) correa. Tetrahedron, 1966, 22(10): 3245-3252.

[2]. Kawaii S, et al. The antiproliferative effect of acridone alkaloids on several cancer cell lines. J Nat Prod. 1999 Apr;62(4):587-9. [Content Brief]

[3]. Kawaii S, et al. Acridones as inducers of HL-60 cell differentiation. Leuk Res. 1999 Mar;23(3):263-9. [Content Brief]

[4]. Leu YL, et al. Antiplatelet aggregation principles from Glycosmis citrifolia. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 1998;12(S1):S77-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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