Acridones as inducers of HL-60 cell differentiation

  • Leuk Res. 1999 Mar;23(3):263-9. doi: 10.1016/s0145-2126(98)00174-x.
S Kawaii  1 ,  Y Tomono ,  E Katase ,  K Ogawa ,  M Yano ,  Y Takemura ,  M Ju-ichi ,  C Ito ,  H Furukawa
Affiliations
  • 1. National Institute of Fruit Tree Science, Shimizu, Shizuoka, Japan.
PMID: 10071079 DOI: 10.1016/s0145-2126(98)00174-x
Abstract

Fifteen Acridone Alkaloids were examined for their activity of induction of human promyelocytic leukemia cell (HL-60) differentiation. HL-60 cells were differentiated into mature monocyte/macrophage by atalaphyllidine (9), atalaphyllinine (12), and des-N-methylnoracronycine (13). The activities of NBT reduction, nonspecific esterase, and phagocytosis, were induced by 2.5 microM of 9, 12, and 13. After a 4-day treatment, 9, 12, and 13 at 10 microM inhibited clonal proliferation of HL-60 cells by 28, 96, and 63%, respectively. The structure-activity relationship established from the results revealed that hydroxyl group at C-1 and prenyl group at C-2 had an important role.

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