1. Immunology/Inflammation
    Metabolic Enzyme/Protease
    JAK/STAT Signaling
    Stem Cell/Wnt
  2. PD-1/PD-L1
    HIF/HIF Prolyl-Hydroxylase
    STAT
  3. Fraxinellone

Fraxinellone 

Cat. No.: HY-N0242 Purity: 99.99%
Handling Instructions

Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.

For research use only. We do not sell to patients.

Fraxinellone Chemical Structure

Fraxinellone Chemical Structure

CAS No. : 28808-62-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
20 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1[1].

In Vitro

Fraxinellone (0-100 μM;12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells[1].

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 0 μM, 10 μM, 30 μM, 100 μM
Incubation Time: 12 hours
Result: Inhibited the percent of PD-L1 positive cells.
In Vivo

Fraxinellone (oral gavage; 30 and 100 mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice[1].

Animal Model: BALB/c nude mice[1]
Dosage: 30 and 100 mg/kg
Administration: Oral gavage; 30 and 100 mg/kg; every three days; 30 days
Result: Significantly suppressed tumor growth.
Molecular Weight

232.28

Formula

C₁₄H₁₆O₃

CAS No.

28808-62-0

SMILES

O=C1O[[email protected]@H](C2=COC=C2)[[email protected]]3(C)CCCC(C)=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (430.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3051 mL 21.5257 mL 43.0515 mL
5 mM 0.8610 mL 4.3051 mL 8.6103 mL
10 mM 0.4305 mL 2.1526 mL 4.3051 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FraxinellonePD-1/PD-L1HIF/HIF Prolyl-HydroxylaseSTATPD-1/Programmed death-ligand 1Hypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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Fraxinellone
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