1. Apoptosis
  2. Apoptosis
  3. Periplocin

Periplocin 

Cat. No.: HY-N1381 Purity: 99.79%
Handling Instructions

Periplocin is a cardiotonic steroid isolated from Periploca forrestii. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase.

For research use only. We do not sell to patients.

Periplocin Chemical Structure

Periplocin Chemical Structure

CAS No. : 13137-64-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 123 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
20 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Periplocin is a cardiotonic steroid isolated from Periploca forrestii. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase[1][2].

IC50 & Target

Apoptosis[2]

In Vitro

Periplocin (5-20 μM; 48 hours; L929 cells) treatment shows increased proliferation up to 131% at 20 μM[1].
Periplocin (5-20 μM; 30-120 minutes; L929 cells) increases phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner. Periplocin (5-20 μM; 48 hours) significantly promotes migration of fibroblast cell[1].
Periplocin (5-20 μM; 48 hours) increases collagen production in L929 fibroblast[1].
Periplocin induces Na/KATPase mediates the activation of Src/ERK and PI3K/Akt pathways[1].

Cell Viability Assay[1]

Cell Line: L929 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 48 hours
Result: Showed increased proliferation up to 131% at 20 μM.

Western Blot Analysis[1]

Cell Line: L929 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 30 minutes, 60 minutes, 120 minutes
Result: Increased phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner.
In Vivo

Periplocin (5-20 mg/kg; intraperitoneal injection; daily; for 14 days; female SCID mice) treatment represses the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice[2].

Animal Model: Female SCID mice (6-8 weeks old) injected with Huh-7 cells[2]
Dosage: 5 mg/kg, 20 mg/kg
Administration: Intraperitoneal injection; daily; for 14 days
Result: Repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice.
Molecular Weight

696.82

Formula

C₃₆H₅₆O₁₃

CAS No.

13137-64-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (358.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4351 mL 7.1755 mL 14.3509 mL
5 mM 0.2870 mL 1.4351 mL 2.8702 mL
10 mM 0.1435 mL 0.7175 mL 1.4351 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PeriplocinApoptosisCrdiotonicsteroidPI3KAktSrcERKwoundhealingapoptosistumorInhibitorinhibitorinhibit

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Periplocin
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HY-N1381
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