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Isoforms Recommended:	SMARCA4

Results for "

smarca4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) DNA/RNA Synthesis (1) Drug Intermediate (1) Epigenetic Reader Domain (49) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (3) Molecular Glues (1) Oxidative Phosphorylation (1) Pregnane X Receptor (PXR) (1) PROTACs (50) Small Interfering RNA (siRNA) (3) SWI/SNF Complex (14)
By Research Areas:	Cancer (71) Infection (1) Inflammation/Immunology (1)
Click Chemistry:	Azide (10)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145388

AU-15330 10+ Cited Publications	PROTACs SWI/SNF Complex	Cancer
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, *SMARCA2* and *SMARCA4*. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .

HY-144835

Camibirstat 2 Publications Verification FHD-286	Oxidative Phosphorylation Epigenetic Reader Domain	Cancer
FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia .

HY-119374

BRM/BRG1 ATP Inhibitor-1 Maximum Cited Publications 40 Publications Verification	Epigenetic Reader Domain	Cancer
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 *(SMARCA2)* and brahma related gene 1 *(BRG1)/SMARCA4* ATPase activity inhibitor, both IC₅₀s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity .

HY-128359

ACBI1 10+ Cited Publications	PROTACs SWI/SNF Complex Apoptosis	Cancer
ACBI1 is a potent and cooperative *SMARCA2, SMARCA4* and PBRM1 degrader with DC₅₀s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis .

HY-159607

PRT3789	PROTACs SWI/SNF Complex	Cancer
PRT3789 is a selective SMARCA2 PROTAC degrader (DC₅₀ in HeLa cell: 0.72 nM for SMARCA2, 14 nM for SMARCA4). PRT3789 forms a stable ternary complex with Von Hippel-Lindau (VHL) E3 ligase, induces polyubiquitination at SMARCA2-specific lysine residues, and drives proteasome-dependent SMARCA2 degradation. PRT3789 disrupts SWI/SNF chromatin remodeling complex integrity, induces dissociation of specific subunits, suppresses oncogenic gene expression, reduces chromatin accessibility, and upregulates antigen processing/presentation-related gene expression. PRT3789 induces synthetic lethality, inhibits proliferation and colony formation, and drives tumor growth inhibition and regression in SMARCA4-deficient contexts. PRT3789 can be used for the research of SMARCA4-mutated solid tumors, non-small cell lung cancer, endometrial cancer, colorectal cancer, bladder cancer, esophageal cancer, ovarian cancer, and gastric cancer .

HY-125905

VH032-cyclopropane-F 1 Publications Verification VHL ligand 3; E3 ligase Ligand 19	Ligands for E3 Ligase	Cancer
VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4 .

HY-163410

AU-24118 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer. (Pink: PBRM1/SMARCA2,4 ligand (HY-171774); Blue: CRBN ligand (HY-171775)) .

HY-153361

YD23	PROTACs Epigenetic Reader Domain	Inflammation/Immunology Cancer
YD23 is a selective SMARCA2 PROTAC degrader with DC₅₀ values of 64 nM and 297 nM in H1792 cells and H1975 cells. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells, including cell cycle and cell growth regulatory genes. YD23 selectively inhibits growth of SMARCA4 mutant lung cancer cells. YD23 has potent tumor growth inhibitory activity in SMARCA4-mutant xenografts. YD23 can be used for the study of non-small cell lung cancer (NSCLC) .

HY-144896

FHT-1015 2 Publications Verification	Epigenetic Reader Domain	Cancer
FHT-1015 is a selective *SMARCA4* (IC₅₀ = 4 nM) and *SMARCA2* (IC₅₀ = 5 nM) (also known as BRG1 and BRM) inhibitor. FH-1015 is an allosteric inhibitor that causes conformation change in the BRG1/BRM protein upon interaction with an allosteric site, inhibiting ATPase activity. FH-1015 interferes with tumor cell growth and migration. FH-1015 can be studied in research for uveal melanoma and hematologic cancer ^[4].

HY-176871

*PROTAC SMARCA2 degrader-35*	PROTACs SWI/SNF Complex DNA/RNA Synthesis	Cancer
PROTAC SMARCA2 degrader-35 (Compound 43) is a selective *SMARCA2* PROTAC degrader with a DC₅₀ < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells .

HY-40249

1-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester	Drug Intermediate	Others
1-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester is a drug intermediate that can be used for the preparation of SMARCA bromodomain ligands .

HY-173351

G-6599	Epigenetic Reader Domain	Cancer
G-6599 is a monovalent molecular glue-like degrader of *SMARCA2/SMARCA4*. G-6599 covalently binds to a specific cysteine residue of the E3 ligase FBXO22 in a biotransformation-independent manner, promotes the formation of a ternary complex with SMARCA2/A4, and achieves efficient and specific degradation of the two proteins via the ubiquitin-proteasome pathway. G-6599 is applicable to the research of androgen-dependent prostate cancer and mutant non-small cell lung cancer .

HY-168215

YDR1	PROTACs Epigenetic Reader Domain	Cancer
YDR1 is a potent PROTAC SMARCA2 degrader, with the DC₅₀ of 7.7 nM. YDR1 plays an important role in SMARCA4 mutant cancers(Sturcture Note:(Blue: Cereblon ligand (HY-W087383), Black: linker；Pink: SMARCA2 ligand (HY-44012B)) .

HY-144897

FHT-1204	Epigenetic Reader Domain	Cancer
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

HY-170824

SMD-3236	PROTACs SWI/SNF Complex Epigenetic Reader Domain	Cancer
SMD-3236 is a *SMARCA2* PROTAC degrader with a DC₅₀ of 0.5 nM, a D_max of 98%, and an IC₅₀ of 42.2 nM against human *SMARCA2. SMD-3236 induces proteasome- and ubiquitin-like modification-dependent degradation of SMARCA2* protein by binding to *SMARCA2* and VHL-1. SMD-3236 inhibits the growth of *SMARCA4*-deficient cancer cells. SMD-3236 induces significant and persistent depletion of *SMARCA2* in tumor tissues. SMD-3236 suppresses tumor growth in *SMARCA4*-deficient human cancer xenograft models. SMD-3236 can be used in research related to *SMARCA4*-deficient cancers such as melanoma, non-small cell lung cancer, and acute myeloid leukemia .

HY-149026

GNE-064	Epigenetic Reader Domain	Others
GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of *SMARCA4, SMARCA2* and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC₅₀ of 0.035 μM and inhibits SMARCA2 with an EC₅₀ of 0.10 μM. GNE-064 possess K_ds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis .

HY-149458

FHT-2344	Epigenetic Reader Domain	Cancer
FHT-2344, a chemical probe, is a SMARCA4/SMARCA2 ATPase inhibitor with IC₅₀ values of 0.026 μM and 0.013 μM, respectively. FHT-2344 has anticancer activity .

HY-156568

SMD-3040	PROTACs Epigenetic Reader Domain	Cancer
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC₅₀: 12 nM; D_max: 91%). SMD-3040 can inhibit tumor cell proliferation and exhibits antitumor activity. SMD-3040 can be used in the study of tumors such as melanoma . (SMARCA2/4-ligand (HY-171765); HY-112078 VHL ligand (HY-112078))

HY-RS13405

SMARCA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMARCA4 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMARCA4 Human Pre-designed siRNA Set A SMARCA4 Human Pre-designed siRNA Set A

HY-170817

SMI-1074	Ligands for Target Protein for PROTAC SWI/SNF Complex	Cancer
SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers .

HY-175756

SMARCA2/4 degrader-1	Molecular Glues SWI/SNF Complex	Cancer
SMARCA2/4 degrader-1 is a *SMARCA2/4* molecular glue degrader with a DCAF16 EC₅₀ of 110 nM. SMARCA2/4 degrader-1 covalently adducts at cysteine to form a ternary complex with SMARCA2/4 and recruits CUL4 ^DCAF16 and CRL1 ^FBXO22 E3 ligase complexes. SMARCA2/4 degrader-1 induces ubiquitination and proteasomal degradation of SMARCA2/4. SMARCA2/4 degrader-1 can be used for research of SMARCA4-deficient malignancies, non-small cell lung cancer (NSCLC), and colorectal cancer .

HY-168221

YD54	PROTACs	Cancer
YD54 is a PROTAC based *SMARCA2* degrader with a DC₅₀ of 3.5 nM (Red: SMARCA2 degrader (HY-44012B), black: linker, Blue: E3 ligase ligand) .

HY-W494890

SMARCA2-IN-10	Epigenetic Reader Domain	Cancer
SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC₅₀=17.676 μM). SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma .

HY-144720

BRG1-IN-1	SWI/SNF Complex	Cancer
BRG1-IN-1 (Compound 11d) is a potent inhibitor of *SMARCA4/BRG1*. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors .

HY-162835

*PROTAC SMARCA2/4-degrader-28*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of *SMARCA2* and *SMARCA4*(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .

HY-RS23244

Smarca4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smarca4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smarca4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarca4 Rat Pre-designed siRNA Set A Smarca4 Rat Pre-designed siRNA Set A

HY-RS16803

Smarca4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smarca4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smarca4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarca4 Mouse Pre-designed siRNA Set A Smarca4 Mouse Pre-designed siRNA Set A

HY-178215

*PROTAC SMARCA2/4 degrader-40*	PROTACs	Cancer
BRM/BRG1 ligand 4 (Compound 6) is a *SMARCA2/4* PROTAC degrader. BRM/BRG1 ligand 4 exhibits potent degradation activity against both *SMARCA2* and *SMARCA4* in HeLa cells, with DC₅₀ less than 0.1 nM. BRM/BRG1 ligand 4 can be used for the study of cancers associated with *SMARCA2/SMARCA4* abnormalities or SWI/SNF mutations .

HY-171774

*PBRM1/SMARCA2,4-ligand-1*	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, *SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1* is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410) .

HY-159455

*PROTAC SMARCA2/4-degrader-4*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-122645

SMARCA2-IN-4	Epigenetic Reader Domain	Cancer
SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe *SMARCA* by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1(5), *SMARCA2B* and *SMARCA4* with K_d of 124, 262 and 417 nM .

HY-175867

*PROTAC SMARCA2 degrader-34*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-34 (compound 52) is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: < 0.1 μM for *SMARCA2, > 1 μM for SMARCA4). PROTAC SMARCA2 degrader-34 can be used for study of cancer. (Pink: SMARCA*2 ligand (HY-178414) ; Blue: E3 ligand (HY-168055) ; Black: linker) .

HY-161885

SMARCA2-IN-6	Epigenetic Reader Domain	Cancer
SMARCA2-IN-6 is a *SMARCA2* (also known as BRM) inhibitor, with IC₅₀s less than 5 nM for SMARCA2 and SMARCA4. SMARCA2-IN-6 inhibits KRT80 gene expression in H1299 cells (IC₅₀: 26 nM). SMARCA2-IN-6 inhibits proliferation in BRG1-mutant SKMEL5 cells (IC₅₀: 13 nM) .

HY-178225

*PROTAC SMARCA2/4 degrader-39*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4 degrader-39 (Compound 7) is a selective degrader of SMARCA2 (BRM) and SMARCA4 (BRG1) PROTAC. PROTAC SMARCA2/4 degrader-39 is promising for research of oncology, such as non-small cell lung cancer and colorectal cancer . (Pink: BRM/BRG1 ligand 5 (HY-178886); Black: Linker Piperazine (HY-B0912); Blue: (S)-Deoxy-thalidomide (HY-168055))

HY-161887

SMARCA2-IN-8	Epigenetic Reader Domain	Cancer
SMARCA2-IN-8 (Compound 13) is an orally active inhibitor for SWI/SNF chromatin remodeling complexe *SMARCA2* (also known as Brahma homologue, BRM) and *SMARCA4* (also known as Brahma-related gene 1, BRG1) with IC₅₀ of 5 and 6 nM. SMARCA2-IN-8 inhibits the proliferation of SMARCA2 mutated cancer cell SKMEL5 with AAC₅₀ of 5 nM. SMARCA2-IN-8 downregulates the SMARCA2-dependent KRT80 gene expression with AAC₅₀ of 10 nM. SMARCA2-IN-8 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice .

HY-170828

SMD-1087	PROTACs SWI/SNF Complex	Others
SMD-1087 is a PROTAC that selectively targets SMARCA2 (DC₅₀=8 nM, D_max=89%) and SMARCA4 with a DC₅₀ of 1 μM. SMD-1087 consists of the E3 ligase ligand (S,R,S)-AHPC-Me (blue part) (HY-112078), the target protein ligand SMI-1074 (red part) (HY-170817), and the PROTAC linker (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate (black part) (HY-W890392). Among them, its target protein ligand + Linker part corresponds to SMARCA2 Ligand-Linker Conjugate-1 (HY-170829) .

HY-174237

*PBRM1/SMARCA2,4 binder-1*	Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4 binder-1 (Compound 17) is a binder of PBRM1, *SMARCA2, and SMARCA4* (IC₅₀: 0.083, 0.153, and 0.046 μM, respectively) .

HY-182987

SMARCA2/SMARCA4 ligand-1	Ligands for Target Protein for PROTAC SWI/SNF Complex	Cancer
SMARCA2/SMARCA4 ligand-1 is a *SMARCA2/SMARCA4* ligand with K_D values of 1.2 and 10.3 nM. SMARCA2/SMARCA4 ligand-1 binds SMARCA2/4 bromodomain via hydrogen bonds with asparagine and tyrosine residues, and a salt bridge with a glutamate residue. SMARCA2/SMARCA4 ligand-1 shows antiproliferative activity against cancer cells. SMARCA2/SMARCA4 ligand-1 can be used for the research of cancer, such as smarca4 mutant nonsmall cell lung cancer .

HY-162834

*PROTAC SMARCA2/4-degrader-27*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of *SMARCA2* and *SMARCA4. (Blue: CRL2 ^VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA*-BD ligand 1 for PROTAC (HY-44012)) .

HY-169278

*PROTAC SMARCA2 degrader-26*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-26 (compound 45) is a potent *SMARCA2* PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .

HY-161884

SMARCA2/4-IN-1	Epigenetic Reader Domain	Cancer
SMARCA2/4-IN-1 (compound 1) is a potent *SMARCA2* inhibitor with IC₅₀ values of 3.8, 1.7 µM for SMARCA2, SMARCA4, respectively .

HY-163871

*PROTAC SMARCA2/4-degrader-18*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

*PROTAC SMARCA2/4-degrader-17*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

HY-162743

*PROTAC SMARCA2/4-degrader-29*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .

HY-162744

*PROTAC SMARCA2/4-degrader-31*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .

HY-163868

*PROTAC SMARCA2/4-degrader-15*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-15 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))

HY-163877

*PROTAC SMARCA2/4-degrader-19*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-163949); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-125845))

HY-159461

*PROTAC SMARCA2/4-degrader-9*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-162748

*PROTAC SMARCA2/4-degrader-30*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2* in A549 and in MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038)) .

HY-159456

*PROTAC SMARCA2/4-degrader-5*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71784

	SMARCA4 Protein, Human (P.pastoris, His) ATP dependent helicase smarca4; ATP-dependent helicase smarca4; Brahma protein like 1; BRG1; BRG1 protein; BRG1-associated factor 190A; MRD16	Human	P. pastoris
	The SMARCA4 protein is a multifaceted regulator of chromatin remodeling that dynamically alters DNA nucleosome topology through ATP-dependent enzymatic activity. As part of the SWI/SNF complex and the CREST-BRG1 complex, it regulates transcriptional processes, coordinating the release and activating recruitment of calcium-dependent repressor complexes. SMARCA4 Protein, Human (P.pastoris, His) is the recombinant human-derived SMARCA4 protein, expressed by P. pastoris , with N-6*His labeled tag.

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Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (5)
Application:	IHC-P (2) ICC/IF (5) IP (5) WB (5) ELISA (1)
Isotype:	IgG (2) IgG1 (2)
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Modification:	Unmodified (4)

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HY-P86425

	BRG1 Antibody (YA6117) smarca4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase smarca4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	BRG1 Antibody (YA6117) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRG1.

HY-P80575

	BRG1 Antibody (YA817) smarca4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase smarca4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, ICC/IF, IP	Human, Mouse
	BRG1 Antibody (YA817) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BRG1.

HY-P80575A

	BRG1 Antibody (YA817)(PBS only) smarca4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase smarca4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, ICC/IF, IP	Human, Mouse
	BRG1 Antibody (YA817) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BRG1.

HY-P85601

	BRG1 Antibody (YA5293) ATP dependent helicase smarca4; ATP-dependent helicase smarca4; BAF 190; BAF190; BAF190A; Brahma protein homolog 1; Brahma protein like 1; BRG1; BRG1 associated factor 190A; BRG1 protein; BRG1-associated factor 190A; BRM/SWI2 related gene 1; Global transcription activator homologous sequence; global transcription activator snf2l4; Homeotic gene regulator; hSNF2b; Mitotic growth and transcription activator; MRD16; Nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; Protein BRG1; RTPS2; SMARC A4; smarca4; SMCA4_HUMAN; SNF2; SNF2 beta; SNF2 like 4; SNF2-beta; SNF2B; SNF2L4; SNF2LB; Sucrose nonfermenting like 4; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SWI2; Transcription activator BRG1.	WB, ICC/IF, IP	Human, Mouse
	BRG1 Antibody (YA5293) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BRG1.

HY-P80039

	BRG1 Antibody (YA577)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	BRG1 Antibody (YA577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRG1.

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Cat. No.	Product Name		Classification

HY-159455

*PROTAC SMARCA2/4-degrader-4*		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159461

*PROTAC SMARCA2/4-degrader-9*		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159459

*PROTAC SMARCA2/4-degrader-32*		Azide
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159449

*PROTAC SMARCA2 degrader-5*		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

*PROTAC SMARCA2 degrader-7*		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

*PROTAC SMARCA2/4-degrader-8*		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159458

*PROTAC SMARCA2/4-degrader-7*		Azide
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

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