PROTAC SMARCA2/4 degrader-19
PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM.
(Pink: SMARCA2 and SMARCA4 Target protein ligand; Blue: VHL ligand (HY-138678B); Black: linker (HY-163903)).
For research use only. We do not sell to patients.
- CAS No.: 2568277-57-4
- Formula: C50H61N11O5S
- Molecular Weight:928.16
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 2568277-57-4
-
Molecular Weight 928.16
-
Formula C50H61N11O5S
-
SMILES
CC1=NC(N2C3CN(C4=C(N)N=NC(C5=C(C=CC=C5)O)=C4)CC2CC3)=NC=C1[C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-19 Related Classifications
HY-163877 Related Classifications
Powered by Bioz