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Cat. No.: HY-162744

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PROTAC SMARCA2/4 degrader-31

PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2 in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM.
(Pink: SMARCA2 and SMARCA4 ligand (HY-163926); Blue: VHL ligand (HY-W382038); Black: linker (HY-159682)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2568273-83-4
화학식: C₄₄H₅₁N₁₁O₄
분자량:797.95

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC SMARCA2/4 degrader-31 Chemical Structure

CAS No.: 2568273-83-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2 in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM^[1]. (Pink: SMARCA2 and SMARCA4 ligand (HY-163926); Blue: VHL ligand (HY-W382038); Black: linker (HY-159682)).

All PROTACs Isoforms :

All SWI/SNF Complex Isoforms :

Chemical Information

CAS No. 2568273-83-4
분자량 797.95
화학식 C₄₄H₅₁N₁₁O₄
SMILES

OC1=CC=CC=C1C2=CC(N3CC(N4C5=NC(C6CCN([C@H]7CC[C@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)=NC=C5)CCC4C3)=C(N)N=N2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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PROTAC SMARCA2/4 degrader-31

All PROTACs Isoforms

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PROTAC SMARCA2/4 degrader-31 Related Classifications

HY-162744 Related Classifications