E3 ligase Ligand 32
Based on 1 Customer Validation
E3 ligase Ligand 32 (First product in Example 3) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743).
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 2300099-98-1
- Formula: C13H12BrN3O3
- Molecular Weight:338.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
HY-L050
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E3 Ligase Ligand Library
HY-L128
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
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MCE Kinase Hinge Binder Fragment Library
HY-L907
Biological Activity
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VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2300099-98-1
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Appearance Solid
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Molecular Weight 338.16
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Formula C13H12BrN3O3
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Color Off-white to light brown
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SMILES
O=C1NC(=O)C(CC1)N2C3=C(C=C(Br)C=C3)N(C)C2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (295.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9572 mL | 14.7859 mL | 29.5718 mL | 73.9295 mL |
| 5 mM | 0.5914 mL | 2.9572 mL | 5.9144 mL | 14.7859 mL | |
| 10 mM | 0.2957 mL | 1.4786 mL | 2.9572 mL | 7.3930 mL | |
| 15 mM | 0.1971 mL | 0.9857 mL | 1.9715 mL | 4.9286 mL | |
| 20 mM | 0.1479 mL | 0.7393 mL | 1.4786 mL | 3.6965 mL | |
| 25 mM | 0.1183 mL | 0.5914 mL | 1.1829 mL | 2.9572 mL | |
| 30 mM | 0.0986 mL | 0.4929 mL | 0.9857 mL | 2.4643 mL | |
| 40 mM | 0.0739 mL | 0.3696 mL | 0.7393 mL | 1.8482 mL | |
| 50 mM | 0.0591 mL | 0.2957 mL | 0.5914 mL | 1.4786 mL | |
| 60 mM | 0.0493 mL | 0.2464 mL | 0.4929 mL | 1.2322 mL | |
| 80 mM | 0.0370 mL | 0.1848 mL | 0.3696 mL | 0.9241 mL | |
| 100 mM | 0.0296 mL | 0.1479 mL | 0.2957 mL | 0.7393 mL |
E3 ligase Ligand 32 Related Classifications
HY-W382038 Related Classifications
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