PBRM1/SMARCA2,4-ligand-1
PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410).
For research use only. We do not sell to patients.
- CAS No.: 1997321-76-2
- Formula: C16H13N3O
- Molecular Weight:263.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All SWI/SNF Complex Isoforms
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Biological Activity
Chemical Information
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CAS No. 1997321-76-2
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Molecular Weight 263.29
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Formula C16H13N3O
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SMILES
NC1=C(C=C(N=N1)C2=C(C=CC=C2)O)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Taylor, A. M., et al., (2022). GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. Journal of medicinal chemistry, 65(16), 11177–11186. [Content Brief]
[2]. Tongchen He, et al. Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer. bioRxiv [Preprint]. 2024 Mar 2:2024.02.29.582768. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PBRM1/SMARCA2,4-ligand-1 Related Classifications
HY-171774 Related Classifications
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