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Art. -Nr.: HY-162748

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PROTAC SMARCA2/4 degrader-30

PROTAC SMARCA2/4 degrader-30 is a SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-30 induces ubiquitination and proteasome-mediated degradation of proteins. PROTAC SMARCA2/4 degrader-30 is applicable for cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-163926); Blue: VHL ligand (HY-W382038); Black: linker (HY-159684)).

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CAS. Nr.: 2568276-44-6
Formel: C₄₄H₅₁N₁₁O₄
Molecular Weight:797.95

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC SMARCA2/4 degrader-30 Chemical Structure

CAS. Nr.: 2568276-44-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC SMARCA2/4 degrader-30 is a SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-30 induces ubiquitination and proteasome-mediated degradation of proteins. PROTAC SMARCA2/4 degrader-30 is applicable for cancer-related research^[1]. (Pink: SMARCA2 and SMARCA4 ligand (HY-163926); Blue: VHL ligand (HY-W382038); Black: linker (HY-159684)).

IC₅₀ & Target^[1]

SMARCA2

SMARCA4

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle SWI/SNF Complex Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC SMARCA2/4 degrader-30 (I-291) potently degrades SMARCA2 protein in A549 cells after a 24 h incubation, with a DC₅₀ of < 100 nM and a maximum degradation rate of > 90% following 24 h of incubation^[1].
PROTAC SMARCA2/4 degrader-30 (24 h) potently degrades SMARCA2 protein in MV4-11 cells, with a DC₅₀ of less than 100 nM; it also potently degrades SMARCA4 protein in MV4-11 cells, with a DC₅₀ of less than 100 nM and a maximum degradation rate of over 90%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2568276-44-6
Molecular Weight 797.95
Formel C₄₄H₅₁N₁₁O₄
SMILES

OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(C6CCN([C@H]7CC[C@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)C=N5)C3)=C(N)N=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ji N, et al. Smarca degraders and uses thereof. US20230072658A1. USPTO. 2023.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

PROTAC SMARCA2/4 degrader-30

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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PROTAC SMARCA2/4 degrader-30

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle SWI/SNF Complex Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PROTAC SMARCA2/4 degrader-30 Related Classifications

HY-162748 Related Classifications