PROTAC SMARCA2/4 degrader-40
BRM/BRG1 ligand 4 (Compound 6) is a SMARCA2/4 PROTAC degrader. BRM/BRG1 ligand 4 exhibits potent degradation activity against both SMARCA2 and SMARCA4 in HeLa cells, with DC50 less than 0.1 nM. BRM/BRG1 ligand 4 can be used for the study of cancers associated with SMARCA2/SMARCA4 abnormalities or SWI/SNF mutations.
For research use only. We do not sell to patients.
- CAS No.: 3099581-65-1
- Formula: C41H45N9O5
- Molecular Weight:743.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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SMARCA2 |
SMARCA4 |
Chemical Information
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CAS No. 3099581-65-1
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Molecular Weight 743.85
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Formula C41H45N9O5
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SMILES
CC[C@@](N1C2)(CNC3=C1C=C(C4=C(O)C=CC=C4)N=N3)C[C@H]2OC(N=C5)=C(C)C=C5CN(CC6)CCN6C7=CC(C8=O)=C(C=C7)CN8[C@H](C(N9)=O)CCC9=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-40 Related Classifications
HY-178215 Related Classifications
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