3099581-65-1
3099581-65-1
Chemical Structure
PROTAC SMARCA2/4 degrader-40
- CAS No.: 3099581-65-1
- Formula:C41H45N9O5
- Molecular Weight:743.85
InChIKey: JNKYPFPMECWHTK-PAWAFPEZSA-N
SMILES: CC[C@@](N1C2)(CNC3=C1C=C(C4=C(O)C=CC=C4)N=N3)C[C@H]2OC(N=C5)=C(C)C=C5CN(CC6)CCN6C7=CC(C8=O)=C(C=C7)CN8[C@H](C(N9)=O)CCC9=O
Biological Activity: BRM/BRG1 ligand 4 (Compound 6) is a SMARCA2/4 PROTAC degrader. BRM/BRG1 ligand 4 exhibits potent degradation activity against both SMARCA2 and SMARCA4 in HeLa cells, with DC50 less than 0.1 nM. BRM/BRG1 ligand 4 can be used for the study of cancers associated with SMARCA2/SMARCA4 abnormalities or SWI/SNF mutations[1].
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PROTAC SMARCA2/4 degrader-40 | BRM/BRG1 ligand 4 (Compound 6) is a SMARCA2/4 PROTAC degrader. BRM/BRG1 ligand 4 exhibits potent degradation activity against both SMARCA2 and SMARCA4 in HeLa cells, with DC50 less than 0.1 nM. BRM/BRG1 ligand 4 can be used for the study of cancers associated with SMARCA2/SMARCA4 abnormalities or SWI/SNF mutations. | |||||||||||||||||||||
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References
Keywords
