2. PROTAC
  3. PROTACs
  4. YD23

YD23 is a SMARCA2 PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically.

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YD23 Chemical Structure

YD23 Chemical Structure

CAS No. : 2951015-29-3

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5 mg USD 980 In-stock
10 mg USD 1600 In-stock
25 mg USD 3360 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

YD23 is a SMARCA2 PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically[1][2].

IC50 & Target

SMARCA2[1][2]
Molecular Weight

738.76

Formula

C38H39FN8O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOC4=C(F)C=C(CN5CCN(C6=C(N)N=NC(C7=C(O)C=CC=C7)=C6)CC5)C=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (135.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3536 mL 6.7681 mL 13.5362 mL
5 mM 0.2707 mL 1.3536 mL 2.7072 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3536 mL 6.7681 mL 13.5362 mL 33.8405 mL
5 mM 0.2707 mL 1.3536 mL 2.7072 mL 6.7681 mL
10 mM 0.1354 mL 0.6768 mL 1.3536 mL 3.3840 mL
15 mM 0.0902 mL 0.4512 mL 0.9024 mL 2.2560 mL
20 mM 0.0677 mL 0.3384 mL 0.6768 mL 1.6920 mL
25 mM 0.0541 mL 0.2707 mL 0.5414 mL 1.3536 mL
30 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1280 mL
40 mM 0.0338 mL 0.1692 mL 0.3384 mL 0.8460 mL
50 mM 0.0271 mL 0.1354 mL 0.2707 mL 0.6768 mL
60 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5640 mL
80 mM 0.0169 mL 0.0846 mL 0.1692 mL 0.4230 mL
100 mM 0.0135 mL 0.0677 mL 0.1354 mL 0.3384 mL
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YD23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YD232951015-29-3YD 23YD-23PROTACsInhibitorinhibitorinhibit

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