PROTAC SMARCA2/4 degrader-22
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: VHL ligand (HY-163953); Black: linker (HY-W006635)).
For research use only. We do not sell to patients.
- CAS No.: 2568277-48-3
- Formula: C51H61N11O6S
- Molecular Weight:956.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
SMARCA2/4[1]
Chemical Information
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CAS No. 2568277-48-3
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Molecular Weight 956.17
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Formula C51H61N11O6S
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SMILES
NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)OC(C)=O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C=N5)C(CC4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-22 Related Classifications
HY-163875 Related Classifications
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