Bpin-Cyclohexene-COOEt
Based on 1 Customer Validation
Bpin-Cyclohexene-COOEt (Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate) is a PROTAC Linker, which can be used in studies related to PROTAC synthesis, such as serving as the core structure of PROTAC SMARCA2/4 degrader-6 (HY-159457).
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- Pureté : 97.78%
- CAS No.: 1049004-32-1
- Formule: C15H25BO4
- Masse moléculaire:280.17
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Stockage:Pure form -20°C, 3 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Bpin-Cyclohexene-COOEt serves as the linker moiety of PROTAC SMARCA2/4 degrader-6 (HY-159457), a PROTAC degrader targeting SMARCA2 and SMARCA4 with a DC50 of < 100 nM for both proteins, which is applicable to cancer-related research[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1049004-32-1
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Appearance Liquid (Density: 1.036±0.10 g/cm3)
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Masse moléculaire 280.17
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Formule C15H25BO4
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Color Colorless to light yellow
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SMILES
CC1(C)C(C)(C)OB(C2=CCC(C(OCC)=O)CC2)O1
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Synonyms
Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years * The compound is unstable in solutions, freshly prepared is recommended.
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (178.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5693 mL | 17.8463 mL | 35.6926 mL | 89.2315 mL |
| 5 mM | 0.7139 mL | 3.5693 mL | 7.1385 mL | 17.8463 mL | |
| 10 mM | 0.3569 mL | 1.7846 mL | 3.5693 mL | 8.9232 mL | |
| 15 mM | 0.2380 mL | 1.1898 mL | 2.3795 mL | 5.9488 mL | |
| 20 mM | 0.1785 mL | 0.8923 mL | 1.7846 mL | 4.4616 mL | |
| 25 mM | 0.1428 mL | 0.7139 mL | 1.4277 mL | 3.5693 mL | |
| 30 mM | 0.1190 mL | 0.5949 mL | 1.1898 mL | 2.9744 mL | |
| 40 mM | 0.0892 mL | 0.4462 mL | 0.8923 mL | 2.2308 mL | |
| 50 mM | 0.0714 mL | 0.3569 mL | 0.7139 mL | 1.7846 mL | |
| 60 mM | 0.0595 mL | 0.2974 mL | 0.5949 mL | 1.4872 mL | |
| 80 mM | 0.0446 mL | 0.2231 mL | 0.4462 mL | 1.1154 mL | |
| 100 mM | 0.0357 mL | 0.1785 mL | 0.3569 mL | 0.8923 mL |
Bpin-Cyclohexene-COOEt Related Classifications
HY-W006635 Related Classifications
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