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Cat. No.: HY-176871

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PROTAC SMARCA2 degrader-35

PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC₅₀ < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells.
(Pink: SMARCA2 Target protein ligand; Blue: E3 ligase ligand; Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3032998-97-0
Formula: C₃₉H₃₈F₃N₉O₅
Molecular Weight:769.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC SMARCA2 degrader-35 Chemical Structure

CAS No.: 3032998-97-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC₅₀ < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells^[1]^[2]. (Pink: SMARCA2 Target protein ligand; Blue: E3 ligase ligand; Black: linker).

IC₅₀ & Target^[1]

SMARCA4/BRG1/BAF190A

All PROTACs Isoforms :

All SWI/SNF Complex Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

SMARCA2 and SMARCA4 are the core catalytic subunits of the SWUSNF complexes, which play an important role in controlling gene expression by remodeling chromatin. SMARCA4 is mutated in multiple cancers and SMARCA4 -deficient cancer cells can become highly dependent on SMARCA2 for their survival. Therefore, targeting SMARCA2 in SMARCA4 -del eted cancers using selective SMARCA2 degraders induces synthetic lethality, while sparing SMARCA4 wild-type normal cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3032998-97-0
Molecular Weight 769.77
Formula C₃₉H₃₈F₃N₉O₅
SMILES

OC1=C(F)C=CC=C1C2=NN=C3C(N(C[C@H](OC4=NC=C(CN5CCN(C6=CC=C7C(C(N([C@@H]8C(NC(CC8)=O)=O)C7)=O)=C6)CC5)C=C4)C9)[C@@]9(C(F)F)CN3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Corey H B, et al. BRM Targeting Compounds And Associated Methods Of Use. US20240165244A1. 2024-05-23.

[2]. Ito K, et al. Combination treatment regimens - smarca2 degrader with taxane anticancer agent. WO2025194059A1. 2025-09-18.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC SMARCA2 degrader-35

All PROTACs Isoforms

All SWI/SNF Complex Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC SMARCA2 degrader-35 Related Classifications

HY-176871 Related Classifications