3032998-97-0

PROTAC SMARCA2 degrader-35 Chemical Structure
3032998-97-0

Chemical Structure

PROTAC SMARCA2 degrader-35

  • CAS No.: 3032998-97-0
  • Formula:C39H38F3N9O5
  • Molecular Weight:769.77

InChIKey: WJPBLNWFKBJZOL-GDADDIGWSA-N

SMILES: OC1=C(F)C=CC=C1C2=NN=C3C(N(C[C@H](OC4=NC=C(CN5CCN(C6=CC=C7C(C(N([C@@H]8C(NC(CC8)=O)=O)C7)=O)=C6)CC5)C=C4)C9)[C@@]9(C(F)F)CN3)=C2

Biological Activity: PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC50 < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells[1][2].

Cat. No. Product Name Purity Description Pricing
HY-176871 		PROTAC SMARCA2 degrader-35 PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC50 < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells.
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