PROTAC SMARCA2/4 degrader-10
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: VHL ligand (HY-163932); Black: linker (HY-W006635)).
For research use only. We do not sell to patients.
- CAS No.: 2568277-33-6
- Formula: C49H62N10O5S
- Molecular Weight:903.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTAC SMARCA2/4-degrader-10 (compound I-399) (0-1000 nM; 24 h) induces SMARCA2, SMARCA4 protein degradation in MV4-11 cells with DC50 values of <100, <100 nM for SMARCA2, SMARCA4, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568277-33-6
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Molecular Weight 903.15
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Formula C49H62N10O5S
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SMILES
NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)C3=CN(C4CCN(CC4)CC[C@@H]5CC[C@H](CC5)C(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)N=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-10 Related Classifications
HY-163872 Related Classifications
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