PROTAC SMARCA2/4 degrader-8
PROTAC SMARCA2/4 degrader-8 is a SMARCA2/SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-8 induces ubiquitination, proteasome-mediated degradation, and recruits the E3 ubiquitin ligase complex. PROTAC SMARCA2/4 degrader-8 is applicable for cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: VHL ligand (HY-125845); Black: linker (HY-W063924)).
For research use only. We do not sell to patients.
- CAS No.: 2568507-14-0
- Formula: C50H61N11O5S
- Molecular Weight:928.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4 degrader-8 (I-502) (24 h) potently degrades SMARCA2 protein in A549 cells, with a DC50 < 100 nM and a maximum degradation rate > 90% after 24 h of incubation[1].
PROTAC SMARCA2/4 degrader-8 (24 h) potently degrades SMARCA4 protein in MV4-11 cells, with a DC50 < 100 nM and a maximum degradation rate > 90% after 24 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568507-14-0
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Molecular Weight 928.16
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Formula C50H61N11O5S
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SMILES
NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6CCC(CC6)CC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C=N5)C(CC4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-8 Related Classifications
HY-159460 Related Classifications
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