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Cat. No.: HY-162741

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PROTAC SMARCA2/4 degrader-33

PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: Cereblon ligand (HY-163927); Black: linker (HY-162791)).

For research use only. We do not sell to patients.

CAS No.: 2568276-36-6
Formula: C₄₄H₅₁N₁₁O₄
Molecular Weight:797.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC SMARCA2/4 degrader-33 Chemical Structure

CAS No.: 2568276-36-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment^[1]. (Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: Cereblon ligand (HY-163927); Black: linker (HY-162791)).

IC₅₀ & Target

SMARCA2/4^[1]

All PROTACs Isoforms :

Chemical Information

CAS No. 2568276-36-6
Molecular Weight 797.95
Formula C₄₄H₅₁N₁₁O₄
SMILES

OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(C6CCN([C@H]7CC[C@@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)C=N5)C3)=C(N)N=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PROTAC SMARCA2/4 degrader-33

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC SMARCA2/4 degrader-33 Related Classifications

HY-162741 Related Classifications