2568276-36-6
2568276-36-6
Chemical Structure
PROTAC SMARCA2/4 degrader-33
- CAS No.: 2568276-36-6
- Formula:C44H51N11O4
- Molecular Weight:797.95
InChIKey: RFWLQOKSXYWDAV-MDLSMXNNSA-N
SMILES: OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(C6CCN([C@H]7CC[C@@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)C=N5)C3)=C(N)N=N2
Biological Activity: PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
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PROTAC SMARCA2/4 degrader-33 | PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment. | |||||||||||||||||||||
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References
Keywords
