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Cat. No.: HY-169272

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PROTAC SMARCA2 degrader-21

PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC₅₀ of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <1 nM and >100 nM, respectively.
(Pink: SMARCA2 ligand (HY-44824); Blue: VHL ligand (HY-125845); Black: linker (HY-169489)).

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CAS No.: 2891464-61-0
Formule: C₅₄H₆₆N₁₂O₅S
Masse moléculaire:995.24

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC SMARCA2 degrader-21 Chemical Structure

CAS No.: 2891464-61-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC₅₀ of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <1 nM and >100 nM, respectively^[1]. (Pink: SMARCA2 ligand (HY-44824); Blue: VHL ligand (HY-125845); Black: linker (HY-169489)).

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Chemical Information

CAS No. 2891464-61-0
Masse moléculaire 995.24
Formule C₅₄H₆₆N₁₂O₅S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C4CC5(CC(C5)N6CCC(CC6)C7=NC(N8CCN9C%10=CC(C%11=C(C=CC=C%11)O)=NN=C%10NC[C@H]9C8)=NC=C7)C4)=O)=O)O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang Y, et al., Smarca degraders and uses thereof. WO2023278402.

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PROTAC SMARCA2 degrader-21

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform SWI/SNF Complex

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC SMARCA2 degrader-21 Related Classifications

HY-169272 Related Classifications

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