2891464-61-0
2891464-61-0
Chemical Structure
PROTAC SMARCA2 degrader-21
- CAS No.: 2891464-61-0
- Formula:C54H66N12O5S
- Molecular Weight:995.24
InChIKey: MAJUVMYADBRQDI-OQZVDIJESA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C4CC5(CC(C5)N6CCC(CC6)C7=NC(N8CCN9C%10=CC(C%11=C(C=CC=C%11)O)=NN=C%10NC[C@H]9C8)=NC=C7)C4)=O)=O)O)=O
Biological Activity: PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <1 nM and >100 nM, respectively[1].
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PROTAC SMARCA2 degrader-21 | PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <1 nM and >100 nM, respectively. | |||||||||||||||||||||
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References
Keywords
