PROTAC SMARCA2/4 degrader-20
PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM
(Pink: SMARCA2 and SMARCA4 ligand (HY-159545); Blue: VHL ligand (HY-125845); Black: linker (HY-W006635)).
For research use only. We do not sell to patients.
- CAS No.: 2568277-38-1
- Formula: C50H58F3N11O6S
- Molecular Weight:998.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2568277-38-1
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Molecular Weight 998.13
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Formula C50H58F3N11O6S
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SMILES
NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=C(C=C(C9=C(N=CS9)C)C=C8)OC(F)(F)F)=O)=O)=O)C=N5)C(CC4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-20 Related Classifications
HY-163873 Related Classifications
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