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Cat. No.: HY-180428

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BRM/BRG1 ATP degrader-1

BRM/BRG1 ATP degrader-1 is a phenol derivative that effectively degrades the BRM protein. BRM/BRG1 ATP degrader-1 exerts degradation-inhibiting effects on BRM IF and BRG1 IF in SW1573 cells. BRM/BRG1 ATP degrader-1 can be used in studies related to BRM-mediated diseases, such as non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2901804-30-4
Formula: C₂₉H₃₄N₈O
Molecular Weight:510.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

BRM/BRG1 ATP degrader-1 Chemical Structure

CAS No.: 2901804-30-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

PBRM1

All SWI/SNF Complex Isoforms :

In Vitro

BRM/BRG1 ATP degrader-1 (compound 1) is a dual degrader of BRM/BRG1. In BRM-HiBiT KI HeLa cells, its HiBiT activity values are -87.0122 at 1 μM and -81.2914 at 10 μM, indicating that it effectively degrades BRM protein^[1].
BRM/BRG1 ATP degrader-1 exhibits degradation inhibition rates (S_inf) ranging from -71% to -120% for both BRM IF and BRG1 IF in SW1573 cells; its IC₅₀ value for BRM IF falls between 0.010-0.10 μM, while the IC₅₀ value for BRG1 IF exceeds 0.10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2901804-30-4
Molecular Weight 510.65
Formula C₂₉H₃₄N₈O
SMILES

OC1=CC=CC=C1C=2N=NC(N)=C(C2)N3CC4N(C=5C=CN=C(C#CCCN6CCNCC6)C5)C(C3)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Villemure E, et al. Phenol derivatives for use in the modulation of brm. WO2023018648A1, WIPO, 2023.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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