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Cat. No.: HY-178225

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PROTAC SMARCA2/4 degrader-39

PROTAC SMARCA2/4 degrader-39 is a SMARCA2 and SMARCA4 PROTAC degrader with DC₅₀ values of < 0.1 nM and 0.1-<1 nM, respectively. PROTAC SMARCA2/4 degrader-39 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-39 is applicable to cervical cancer research.
(Pink: SMARCA2 and SMARCA4 Target protein ligand; Blue: Cereblon ligand (HY-168055); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3099581-74-2
Formula: C₄₁H₄₃N₉O₆
Molecular Weight:757.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PROTAC SMARCA2/4 degrader-39 Chemical Structure

CAS No.: 3099581-74-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC SMARCA2/4 degrader-39 is a SMARCA2 and SMARCA4 PROTAC degrader with DC₅₀ values of < 0.1 nM and 0.1-<1 nM, respectively. PROTAC SMARCA2/4 degrader-39 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-39 is applicable to cervical cancer research^[1]. (Pink: SMARCA2 and SMARCA4 Target protein ligand; Blue: Cereblon ligand (HY-168055); Black: linker).

IC₅₀ & Target

^[1]

SMARCA2

< 0.1 nM (DC₅₀)

SMARCA4

0.1-<1 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All SWI/SNF Complex Isoforms :

In Vitro

PROTAC SMARCA2/4 degrader-39 (Compound 7) degrades SMARCA2 and SMARCA4 in HeLa cells, with DC₅₀ values of < 0.1 nM and 0.1-<1 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3099581-74-2
Molecular Weight 757.84
Formula C₄₁H₄₃N₉O₆
SMILES

CC[C@@](N1C2)(CNC3=C1C=C(C4=C(O)C=CC=C4)N=N3)C[C@H]2OC(N=C5)=C(C)C=C5C(N(CC6)CCN6C7=CC(C8=O)=C(C=C7)CN8[C@H](C(N9)=O)CCC9=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patent citations (16), et al. Brm and brg1 targeting compounds and associated methods of use. WO2025184459A1. 2026-09-01.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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