SMI-1074
SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers.
For research use only. We do not sell to patients.
- CAS No.: 3033592-13-8
- Formula: C25H26ClN3O
- Molecular Weight:419.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All SWI/SNF Complex Isoforms
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Biological Activity
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SMARCA2 66 nM (IC50) |
SMARCA4 83 nM (IC50) |
SMI-1074 binds to purified human SMARCA2 and SMARCA4 bromodomains with IC50 values of 66 nM and 83 nM, respectively[1].
SMI-1074 (10 μM; 2 h) pretreatment of HeLa cells blocks SMD-3236-induced degradation of SMARCA2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033592-13-8
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Molecular Weight 419.95
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Formula C25H26ClN3O
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SMILES
ClC1=CC=CC(N2C(C3(C4=C2C=C(C=C4)C5CCNCC5)CCCCC3)=N6)=C1C6=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yang L, et al. Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers. J Med Chem. 2025;68(2):1155-1178. [Content Brief]
[2]. Leng L, et al. Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders. J Med Chem. 2025;68(2):1113-1133. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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