2. PROTAC Cell Cycle/DNA Damage
  3. Ligands for Target Protein for PROTAC SWI/SNF Complex
  4. SMI-1074

SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers.

For research use only. We do not sell to patients.

SMI-1074

SMI-1074 Chemical Structure

CAS No. : 3033592-13-8

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25 mg Get quote 7 - 9 weeks 6 - 8 weeks 8 - 10 weeks 6 - 8 weeks
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SMI-1074 Related Antibodies

Top Publications Citing Use of Products

View All SWI/SNF Complex Isoform Specific Products:

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SMARCA2 SMARCA4 Protein Polybromo-1

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Description

SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers[1][2].

IC50 & Target[1]

SMARCA2

66 nM (IC50)

SMARCA4

83 nM (IC50)

In Vitro

SMI-1074 binds to purified human SMARCA2 and SMARCA4 bromodomains with IC50 values of 66 nM and 83 nM, respectively[1].
SMI-1074 (10 μM; 2 h) pretreatment of HeLa cells blocks SMD-3236-induced degradation of SMARCA2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMI-1074 Related Antibodies
Molecular Weight

419.95

Formula

C25H26ClN3O
CAS No.
SMILES

ClC1=CC=CC(N2C(C3(C4=C2C=C(C=C4)C5CCNCC5)CCCCC3)=N6)=C1C6=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMI-1074 Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMI-10743033592-13-8SMI1074SMI 1074Ligands for Target Protein for PROTACSWI/SNF ComplexTarget Protein-binding MoietySWI/SNF Family of Chromatin-Remodelling ComplexesSMARCA bromodomainSMARCA4 bromodomainrecombinant human SMARCA2 bromodomainrecombinant human SMARCA4 bromodomainSMARCA2 bromodomainHeLa cellssmarca4-deficient human cancersInhibitorinhibitorinhibit

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SMI-1074
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HY-170817
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