3033592-13-8
3033592-13-8
Chemical Structure
SMI-1074
- CAS No.: 3033592-13-8
- Formula:C25H26ClN3O
- Molecular Weight:419.95
InChIKey: JKAGLEAKJQWJPR-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(N2C(C3(C4=C2C=C(C=C4)C5CCNCC5)CCCCC3)=N6)=C1C6=O
Biological Activity: SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers[1][2].
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SMI-1074 | SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers. | |||||||||||||||||||||
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References
- [1]. Yang L, et al. Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers. J Med Chem. 2025;68(2):1155-1178. [Content Brief]
- [2]. Leng L, et al. Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders. J Med Chem. 2025;68(2):1113-1133. [Content Brief]
Keywords
