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  4. SMD-3040 formate

SMD-3040 formate is a potent and selective smarca2 protac degrader with strong in vivo antitumor activity.

For research use only. We do not sell to patients.

SMD-3040 formate Chemical Structure

SMD-3040 formate Chemical Structure

Size Price Stock Quantity
1 mg USD 800 In-stock
5 mg USD 2000 In-stock
10 mg USD 3500 In-stock
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Based on 1 publication(s) in Google Scholar

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SMD-3040 formate Related Antibodies

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Description

SMD-3040 formate is a potent and selective smarca2 protac degrader with strong in vivo antitumor activity[1].

Molecular Weight

989.23

Formula

C53H68N10O7S
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C(C)(C)C)[C@H]4CC[C@H](CN5CC6(CCC(N7N=CC(C8=C(N)N=NC(C9=C(O)C=CC=C9)=C8)=C7)CC6)C5)CC4.O=CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (101.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0109 mL 5.0544 mL 10.1089 mL
5 mM 0.2022 mL 1.0109 mL 2.0218 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0109 mL 5.0544 mL 10.1089 mL 25.2722 mL
5 mM 0.2022 mL 1.0109 mL 2.0218 mL 5.0544 mL
10 mM 0.1011 mL 0.5054 mL 1.0109 mL 2.5272 mL
15 mM 0.0674 mL 0.3370 mL 0.6739 mL 1.6848 mL
20 mM 0.0505 mL 0.2527 mL 0.5054 mL 1.2636 mL
25 mM 0.0404 mL 0.2022 mL 0.4044 mL 1.0109 mL
30 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8424 mL
40 mM 0.0253 mL 0.1264 mL 0.2527 mL 0.6318 mL
50 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.5054 mL
60 mM 0.0168 mL 0.0842 mL 0.1685 mL 0.4212 mL
80 mM 0.0126 mL 0.0632 mL 0.1264 mL 0.3159 mL
100 mM 0.0101 mL 0.0505 mL 0.1011 mL 0.2527 mL
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SMD-3040 formate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMD-3040 formatePROTACsantitumor activitysmarca2 protac degraderInhibitorinhibitorinhibit

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