SMD-3040

Cat. No.: HY-156568: FAQs
Data Sheet Handling Instructions

Molarity Calculator

SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC₅₀: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models.

For research use only. We do not sell to patients.

SMD-3040 Chemical Structure

CAS No. : 3033109-92-8

Size	Price	Stock
1 mg	USD 800	Ask For Quote & Lead Time
5 mg	USD 2000	Ask For Quote & Lead Time
10 mg	USD 3500	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of SMD-3040:

SMD-3040 TFA SMD-3040 formate

Other Forms of SMD-3040:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

943.21

Formula

C₅₂H₆₆N₁₀O₅S

CAS No.

3033109-92-8

SMILES

O=C(N[C@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C(C)(C)C)[C@H]4CC[C@H](CN5CC6(CCC(N7N=CC(C8=C(N)N=NC(C9=C(O)C=CC=C9)=C8)=C7)CC6)C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (106.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0602 mL	5.3010 mL	10.6021 mL
5 mM	0.2120 mL	1.0602 mL	2.1204 mL
10 mM	0.1060 mL	0.5301 mL	1.0602 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0602 mL	5.3010 mL	10.6021 mL	26.5052 mL
	5 mM	0.2120 mL	1.0602 mL	2.1204 mL	5.3010 mL
	10 mM	0.1060 mL	0.5301 mL	1.0602 mL	2.6505 mL
	15 mM	0.0707 mL	0.3534 mL	0.7068 mL	1.7670 mL
	20 mM	0.0530 mL	0.2651 mL	0.5301 mL	1.3253 mL
	25 mM	0.0424 mL	0.2120 mL	0.4241 mL	1.0602 mL
	30 mM	0.0353 mL	0.1767 mL	0.3534 mL	0.8835 mL
	40 mM	0.0265 mL	0.1325 mL	0.2651 mL	0.6626 mL
	50 mM	0.0212 mL	0.1060 mL	0.2120 mL	0.5301 mL
	60 mM	0.0177 mL	0.0884 mL	0.1767 mL	0.4418 mL
	80 mM	0.0133 mL	0.0663 mL	0.1325 mL	0.3313 mL
	100 mM	0.0106 mL	0.0530 mL	0.1060 mL	0.2651 mL

SMD-3040 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMD-30403033109-92-8SMD3040SMD 3040Epigenetic Reader DomainPROTACsSMARCA2SMARCA4xenograft modelsPROTAC degraderInhibitorinhibitorinhibit

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