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Cat. No.: HY-159453

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PROTAC SMARCA2/4 degrader-2

PROTAC SMARCA2/4 degrader-2 is a PROTAC degrader targeting SMARCA2 and SMARCA4, with a DC₅₀ of < 100 nM for both proteins. PROTAC SMARCA2/4 degrader-2 induces ubiquitination and subsequent proteasome-mediated degradation of SMARCA2 and SMARCA4 proteins. PROTAC SMARCA2/4 degrader-2 can be used in cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-163926); Blue: E3 Ligase Ligand-Linker Conjugates ligand (HY-159556); Black: linker (HY-159592)).

For research use only. We do not sell to patients.

CAS No.: 2568277-76-7
Formula: C₅₂H₆₄N₁₂O₆S
Molecular Weight:985.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PROTAC SMARCA2/4 degrader-2 Chemical Structure

CAS No.: 2568277-76-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC SMARCA2/4 degrader-2 is a PROTAC degrader targeting SMARCA2 and SMARCA4, with a DC₅₀ of < 100 nM for both proteins. PROTAC SMARCA2/4 degrader-2 induces ubiquitination and subsequent proteasome-mediated degradation of SMARCA2 and SMARCA4 proteins. PROTAC SMARCA2/4 degrader-2 can be used in cancer-related research^[1]. (Pink: SMARCA2 and SMARCA4 ligand (HY-163926); Blue: E3 Ligase Ligand-Linker Conjugates ligand (HY-159556); Black: linker (HY-159592)).

IC₅₀ & Target^[1]

SMARCA2

SMARCA4

All PROTACs Isoforms :

All SWI/SNF Complex Isoforms :

In Vitro

PROTAC SMARCA2/4 degrader-2 (I-431) (24 h) potently degrades SMARCA2 protein in A549 cells with a DC₅₀ < 100 nM and > 90% maximum degradation after 24 hours^[1].
PROTAC SMARCA2/4 degrader-2 (24 h) potently degrades both SMARCA2 and SMARCA4 proteins in MV4-11 cells, with a DC₅₀ < 100 nM and > 90% maximum degradation for both proteins after 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2568277-76-7
Molecular Weight 985.21
Formula C₅₂H₆₄N₁₂O₆S
SMILES

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@H]6CC[C@@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=C(C=C(C9=C(N=CS9)C)C=C8)C(N(C)C)=O)=O)=O)=O)C=N5)C(CC4)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ji N, et al. Smarca degraders and uses thereof. US20230072658A1. USPTO. 2023.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC SMARCA2/4 degrader-2

All PROTACs Isoforms

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC SMARCA2/4 degrader-2 Related Classifications

HY-159453 Related Classifications