2568277-76-7
2568277-76-7
Chemical Structure
PROTAC SMARCA2/4 degrader-2
- CAS. Nr.: 2568277-76-7
- Formula:C52H64N12O6S
- Molecular Weight:985.21
InChIKey: PLXHPTSUVOXDCO-INBBVLNLSA-N
SMILES: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@H]6CC[C@@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=C(C=C(C9=C(N=CS9)C)C=C8)C(N(C)C)=O)=O)=O)=O)C=N5)C(CC4)C3
Biological Activity: PROTAC SMARCA2/4 degrader-2 is a PROTAC degrader targeting SMARCA2 and SMARCA4, with a DC50 of < 100 nM for both proteins. PROTAC SMARCA2/4 degrader-2 induces ubiquitination and subsequent proteasome-mediated degradation of SMARCA2 and SMARCA4 proteins. PROTAC SMARCA2/4 degrader-2 can be used in cancer-related research[1].
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PROTAC SMARCA2/4 degrader-2 | PROTAC SMARCA2/4 degrader-2 is a PROTAC degrader targeting SMARCA2 and SMARCA4, with a DC50 of < 100 nM for both proteins. PROTAC SMARCA2/4 degrader-2 induces ubiquitination and subsequent proteasome-mediated degradation of SMARCA2 and SMARCA4 proteins. PROTAC SMARCA2/4 degrader-2 can be used in cancer-related research. | |||||||||||||||||||||
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