2. Cell Cycle/DNA Damage
  3. SWI/SNF Complex
  4. SMARCA2/4-IN-4

SMARCA2-IN-6 is a SMARCA2 and SMARCA4 inhibitor, with an IC50 value of <0.005 μM for both SMARCA2 and SMARCA4. SMARCA2-IN-6 exerts anticancer activity against BRG1-mutant melanoma. SMARCA2-IN-6 can be used for research related to Brg1/Smarca4-mutant cancers.

For research use only. We do not sell to patients.

SMARCA2/4-IN-4

SMARCA2/4-IN-4 Chemical Structure

CAS No. : 2270875-79-9

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SMARCA2/4-IN-4 Related Antibodies

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SMARCA2 SMARCA4 Protein Polybromo-1

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Description

SMARCA2-IN-6 is a SMARCA2 and SMARCA4 inhibitor, with an IC50 value of <0.005 μM for both SMARCA2 and SMARCA4. SMARCA2-IN-6 exerts anticancer activity against BRG1-mutant melanoma. SMARCA2-IN-6 can be used for research related to Brg1/Smarca4-mutant cancers[1].

IC50 & Target[1]

SMARCA2

<0.005 μM (IC50)

SMARCA4

<0.005 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
SBC-5 EC50
>10 μM
Compound: 11
Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
[PMID: 30339381]
In Vitro

SMARCA2-IN-6 (Compound 11) potently inhibits the ATPase activity of truncated BRM ATPase−SnAC and BRG1 ATPase−SnAC proteins, with an IC50 of <0.005 μM for both targets[1].
SMARCA2-IN-6 inhibits the expression of the KRT80 gene in BRG1-mutant H1299 cells, with an AAC50 of 0.026 μM[1].
SMARCA2-IN-6 potently inhibits the proliferation of BRG1-mutant SKMEL5 cells with an AAC50 of 0.013 μM, while it shows no significant activity in SBC5 cells with BRM-BRG1 target deletion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMARCA2/4-IN-4 Related Antibodies
Molecular Weight

319.72

Formula

C10H8ClF2N5OS
CAS No.
SMILES

O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMARCA2/4-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARCA2/4-IN-42270875-79-9SWI/SNF ComplexSWI/SNF Family of Chromatin-Remodelling ComplexesBRM-dependent gene expressionBRG1-mutant SKMEL5 cellsSWI/SNFBRG1-mutant H1299 cellsKRT80 gene expressionSBC5 cellsBRG1-mutant cancer cellsSMARCA2SMARCA4BRG1-mutant lung tumor xenograft modelsInhibitorinhibitorinhibit

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