SMARCA2/4-IN-4
SMARCA2-IN-6 is a SMARCA2 and SMARCA4 inhibitor, with an IC50 value of <0.005 μM for both SMARCA2 and SMARCA4. SMARCA2-IN-6 exerts anticancer activity against BRG1-mutant melanoma. SMARCA2-IN-6 can be used for research related to Brg1/Smarca4-mutant cancers.
For research use only. We do not sell to patients.
- CAS No.: 2270875-79-9
- Formula: C10H8ClF2N5OS
- Molecular Weight:319.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All SWI/SNF Complex Isoforms
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Biological Activity
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SMARCA2 <0.005 μM (IC50) |
SMARCA4 <0.005 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| SBC-5 | EC50 |
>10 μM
Compound: 11
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Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
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[PMID: 30339381] |
SMARCA2-IN-6 (Compound 11) potently inhibits the ATPase activity of truncated BRM ATPase−SnAC and BRG1 ATPase−SnAC proteins, with an IC50 of <0.005 μM for both targets[1].
SMARCA2-IN-6 inhibits the expression of the KRT80 gene in BRG1-mutant H1299 cells, with an AAC50 of 0.026 μM[1].
SMARCA2-IN-6 potently inhibits the proliferation of BRG1-mutant SKMEL5 cells with an AAC50 of 0.013 μM, while it shows no significant activity in SBC5 cells with BRM-BRG1 target deletion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2270875-79-9
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Molecular Weight 319.72
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Formula C10H8ClF2N5OS
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SMILES
O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMARCA2/4-IN-4 Related Classifications
HY-161885 Related Classifications
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