PROTAC SMARCA2/4 degrader-28
PROTAC SMARCA2/4 degrader-28 is a heterobifunctional PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-28 forms a ternary complex with CRL2VHL E3 ligase and SMARCA2 or SMARCA4, mediating the ubiquitination and degradation of SMARCA2, while acting as a partial degrader of SMARCA4. PROTAC SMARCA2/4-degrader-28 can be used in cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-13030); Blue: VHL ligand (HY-125845); Black: linker (HY-159680)).
For research use only. We do not sell to patients.
- CAS No.: 2409844-88-6
- Formula: C54H68ClN9O11S2
- Molecular Weight:1118.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4 degrader-28 (PROTAC 1) forms a positively cooperative (α = 4.8) ternary complex with the purified SMARCA2 bromodomain and CRL2VHL, a property characterized by X-ray crystallography and biophysical analyses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2409844-88-6
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Molecular Weight 1118.75
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Formula C54H68ClN9O11S2
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N[C@@H]4COCCOCCOC5=CC(C6=C(N=CS6)C)=CC=C5CNC([C@@]7([H])N(C[C@@H](C7)O)C([C@@H](NC(COCCOCCOC4)=O)C(C)(C)C)=O)=O)=O)C8=NN=C(C)N28
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-28 Related Classifications
HY-162835 Related Classifications
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