2409844-88-6
Chemical Structure
PROTAC SMARCA2/4 degrader-28
- CAS No.: 2409844-88-6
- Formula:C54H68ClN9O11S2
- Molecular Weight:1118.75
InChIKey: GMEHQGWGMMKWAX-NIQMDXQVSA-N
SMILES: CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N[C@@H]4COCCOCCOC5=CC(C6=C(N=CS6)C)=CC=C5CNC([C@@]7([H])N(C[C@@H](C7)O)C([C@@H](NC(COCCOCCOC4)=O)C(C)(C)C)=O)=O)=O)C8=NN=C(C)N28
Biological Activity: PROTAC SMARCA2/4 degrader-28 is a heterobifunctional PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-28 forms a ternary complex with CRL2VHL E3 ligase and SMARCA2 or SMARCA4, mediating the ubiquitination and degradation of SMARCA2, while acting as a partial degrader of SMARCA4. PROTAC SMARCA2/4-degrader-28 can be used in cancer-related research[1].
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PROTAC SMARCA2/4 degrader-28 | PROTAC SMARCA2/4 degrader-28 is a heterobifunctional PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-28 forms a ternary complex with CRL2VHL E3 ligase and SMARCA2 or SMARCA4, mediating the ubiquitination and degradation of SMARCA2, while acting as a partial degrader of SMARCA4. PROTAC SMARCA2/4-degrader-28 can be used in cancer-related research. | |||||||||||||||||||||
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