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Cat. No.: HY-174237

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PBRM1/SMARCA2,4 binder-1

PBRM1/SMARCA2,4 binder-1 (Compound 17) is a binder of PBRM1, SMARCA2, and SMARCA4 (IC₅₀: 0.083, 0.153, and 0.046 μM, respectively).

For research use only. We do not sell to patients.

Formula: C₁₇H₁₃N₃O₂
Molecular Weight:291.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PBRM1/SMARCA2,4 binder-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PBRM1/SMARCA2,4 binder-1 (Compound 17) is a binder of PBRM1, SMARCA2, and SMARCA4 (IC₅₀: 0.083, 0.153, and 0.046 μM, respectively)^[1].

All SWI/SNF Complex Isoforms :

Chemical Information

Molecular Weight 291.30
Formula C₁₇H₁₃N₃O₂
SMILES

OC1=C2C(NC(N=C(CC3=CC=CC=C3)N4)=C2C4=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Boerth J A, et al. Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders[J]. ACS Medicinal Chemistry Letters, 2025.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
Purity & Documentation
References

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PBRM1/SMARCA2,4 binder-1

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PBRM1/SMARCA2,4 binder-1 Related Classifications

HY-174237 Related Classifications